The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation

Florian Sparber; Corinne De Gregorio; Simone Steckholzer; Filipa M. Ferreira; Tamas Dolowschiak; Fiorella Ruchti; Florian R. Kirchner; Sarah Mertens; Immo Prinz; Nicole Joller; Thorsten Buch; Martin Glatz; Federica Sallusto; Salomé LeibundGut-Landmann

doi:10.1016/j.chom.2019.02.002

The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation

Florian Sparber, Corinne De Gregorio, Simone Steckholzer, Filipa M. Ferreira, Tamas Dolowschiak, Fiorella Ruchti, Florian R. Kirchner, Sarah Mertens, Immo Prinz, Nicole Joller, Thorsten Buch, Martin Glatz, Federica Sallusto, Salomé LeibundGut-Landmann

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

The skin commensal yeast Malassezia is associated with common skin disorders like atopic dermatitis, but how the mammalian host responds to Malassezia remains unclear. Using an epicutaneous infection model in mice, Sparber et al. demonstrate that the IL-23-IL-17 pathway controls fungal colonization and also drives Malassezia-induced inflammation in atopy-like skin.

Original language	English
Pages (from-to)	389-403.e6
Journal	Cell Host and Microbe
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2019.02.002
State	Published - 13 Mar 2019
Externally published	Yes

Keywords

Malassezia
Th17
atopic dermatitis
fungal commensalism
inflammation
interleukin-17
interleukin-23
skin immunity
skin microbiota
γδ T cells

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10.1016/j.chom.2019.02.002

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Sparber, F., De Gregorio, C., Steckholzer, S., Ferreira, F. M., Dolowschiak, T., Ruchti, F., Kirchner, F. R., Mertens, S., Prinz, I., Joller, N., Buch, T., Glatz, M., Sallusto, F., & LeibundGut-Landmann, S. (2019). The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation. Cell Host and Microbe, 25(3), 389-403.e6. https://doi.org/10.1016/j.chom.2019.02.002

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title = "The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation",

abstract = "The skin commensal yeast Malassezia is associated with common skin disorders like atopic dermatitis, but how the mammalian host responds to Malassezia remains unclear. Using an epicutaneous infection model in mice, Sparber et al. demonstrate that the IL-23-IL-17 pathway controls fungal colonization and also drives Malassezia-induced inflammation in atopy-like skin.",

keywords = "Malassezia, Th17, atopic dermatitis, fungal commensalism, inflammation, interleukin-17, interleukin-23, skin immunity, skin microbiota, γδ T cells",

author = "Florian Sparber and {De Gregorio}, Corinne and Simone Steckholzer and Ferreira, {Filipa M.} and Tamas Dolowschiak and Fiorella Ruchti and Kirchner, {Florian R.} and Sarah Mertens and Immo Prinz and Nicole Joller and Thorsten Buch and Martin Glatz and Federica Sallusto and Salom{\'e} LeibundGut-Landmann",

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year = "2019",

month = mar,

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doi = "10.1016/j.chom.2019.02.002",

language = "English",

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Sparber, F, De Gregorio, C, Steckholzer, S, Ferreira, FM, Dolowschiak, T, Ruchti, F, Kirchner, FR, Mertens, S, Prinz, I, Joller, N, Buch, T, Glatz, M, Sallusto, F & LeibundGut-Landmann, S 2019, 'The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation', Cell Host and Microbe, vol. 25, no. 3, pp. 389-403.e6. https://doi.org/10.1016/j.chom.2019.02.002

TY - JOUR

T1 - The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation

AU - Sparber, Florian

AU - De Gregorio, Corinne

AU - Steckholzer, Simone

AU - Ferreira, Filipa M.

AU - Dolowschiak, Tamas

AU - Ruchti, Fiorella

AU - Kirchner, Florian R.

AU - Mertens, Sarah

AU - Prinz, Immo

AU - Joller, Nicole

AU - Buch, Thorsten

AU - Glatz, Martin

AU - Sallusto, Federica

AU - LeibundGut-Landmann, Salomé

PY - 2019/3/13

Y1 - 2019/3/13

N2 - The skin commensal yeast Malassezia is associated with common skin disorders like atopic dermatitis, but how the mammalian host responds to Malassezia remains unclear. Using an epicutaneous infection model in mice, Sparber et al. demonstrate that the IL-23-IL-17 pathway controls fungal colonization and also drives Malassezia-induced inflammation in atopy-like skin.

AB - The skin commensal yeast Malassezia is associated with common skin disorders like atopic dermatitis, but how the mammalian host responds to Malassezia remains unclear. Using an epicutaneous infection model in mice, Sparber et al. demonstrate that the IL-23-IL-17 pathway controls fungal colonization and also drives Malassezia-induced inflammation in atopy-like skin.

KW - Malassezia

KW - Th17

KW - atopic dermatitis

KW - fungal commensalism

KW - inflammation

KW - interleukin-17

KW - interleukin-23

KW - skin immunity

KW - skin microbiota

KW - γδ T cells

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U2 - 10.1016/j.chom.2019.02.002

DO - 10.1016/j.chom.2019.02.002

M3 - Article

C2 - 30870621

AN - SCOPUS:85062339958

SN - 1931-3128

VL - 25

SP - 389-403.e6

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 3

ER -

The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation

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