TY - JOUR
T1 - The role of the FOXP3 transcription factor in the immune regulation of allergic asthma
AU - Schmidt-Weber, Carsten B.
AU - Blaser, Kurt
N1 - Funding Information:
This work was supported by the Swiss National Foundation Grants Nr: 3100-065436/2 and 3100A0-100164, the Hartmann Müller Foundation, Zürich, the Bonizzi-Theler Foundation, Zürich, and the Saurer Foundation Davos.
PY - 2005/9
Y1 - 2005/9
N2 - Unbalanced immune reactions against allergens are caused by Th2 cells, which are the basis of immunoglobulin E (IgE)-mediated symptoms of allergy and asthma. Although Th2 cells are essential for allergy, they are not sufficient to cause disease, because regulatory T cells (Tregs) control their activity and expansion. Therefore, Tregs are assumed to play an important role not only in the sensitization but also in established allergic disease under therapy. A key factor of Tregs is FOXP3, which, upon expression, is sufficient to induce regulatory T-cell phenotypes. The initiation and suppressive function of FOXP3 and Tregs in the context of allergic asthma are discussed in this review.
AB - Unbalanced immune reactions against allergens are caused by Th2 cells, which are the basis of immunoglobulin E (IgE)-mediated symptoms of allergy and asthma. Although Th2 cells are essential for allergy, they are not sufficient to cause disease, because regulatory T cells (Tregs) control their activity and expansion. Therefore, Tregs are assumed to play an important role not only in the sensitization but also in established allergic disease under therapy. A key factor of Tregs is FOXP3, which, upon expression, is sufficient to induce regulatory T-cell phenotypes. The initiation and suppressive function of FOXP3 and Tregs in the context of allergic asthma are discussed in this review.
UR - http://www.scopus.com/inward/record.url?scp=28044473224&partnerID=8YFLogxK
U2 - 10.1007/s11882-005-0006-z
DO - 10.1007/s11882-005-0006-z
M3 - Review article
C2 - 16091206
AN - SCOPUS:28044473224
SN - 1529-7322
VL - 5
SP - 356
EP - 361
JO - Current Allergy and Asthma Reports
JF - Current Allergy and Asthma Reports
IS - 5
ER -