TY - JOUR
T1 - The Role of TGF-β in Allergic Inflammation
AU - Schmidt-Weber, Carsten B.
AU - Blaser, Kurt
N1 - Funding Information:
This work was supported by the Swiss National Foundation Grants Nr: 31-65436 and 32-100266 and 3100A0-100164, the Ehmann Foundation, the Saurer Foundation, Bonizzi-Theler Stiftung, and the Ernst-Göhner Stiftung, Zug.
PY - 2006/5
Y1 - 2006/5
N2 - The transforming growth factor β (TGF-β) plays a dual role in allergic disease. It is important in suppressing T cells and also mediates repair responses that lead to unwanted remodeling of tissues. Advances in the immunology of allergy indicate that allergens cause overreactions in the lymphocyte compartment because of the lack or decreased number of suppressive, regulatory T cells. TGF-β was shown to induce regulatory T cells and participate directly in suppression of effector T cells. Therefore, TGF-β may help return reactivity to allergens to normal subsymptomatic activity. Whether chronic inflammatory diseases such as asthma profit from TGF-β-mediated suppression of specific immune responses or whether the TGF-β-mediated tissue remodeling aggravates diseases more than it helps control immune reactions is unclear. This article addresses these issues and future strategies in this field.
AB - The transforming growth factor β (TGF-β) plays a dual role in allergic disease. It is important in suppressing T cells and also mediates repair responses that lead to unwanted remodeling of tissues. Advances in the immunology of allergy indicate that allergens cause overreactions in the lymphocyte compartment because of the lack or decreased number of suppressive, regulatory T cells. TGF-β was shown to induce regulatory T cells and participate directly in suppression of effector T cells. Therefore, TGF-β may help return reactivity to allergens to normal subsymptomatic activity. Whether chronic inflammatory diseases such as asthma profit from TGF-β-mediated suppression of specific immune responses or whether the TGF-β-mediated tissue remodeling aggravates diseases more than it helps control immune reactions is unclear. This article addresses these issues and future strategies in this field.
UR - http://www.scopus.com/inward/record.url?scp=33646421958&partnerID=8YFLogxK
U2 - 10.1016/j.iac.2006.02.011
DO - 10.1016/j.iac.2006.02.011
M3 - Review article
C2 - 16701142
AN - SCOPUS:33646421958
SN - 0889-8561
VL - 26
SP - 233
EP - 244
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
IS - 2
ER -