The role of mitochondrial RNA association for mitochondrial homeostasis in neurons

Inmaculada Segura, Angelika Harbauer

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The sub-compartmentalization of cellular processes is especially important in highly polarized cells such as neurons, as their function rely on their complex morphology. The association of RNAs to the mitochondrial surface is a conserved feature from yeast to humans and it regulates several aspects of mitochondrial physiology and, hence, cellular functions. In neurons, mitochondria are emerging as platforms for RNA transport and local protein translation. In this review, we discuss how RNA localization to mitochondria helps to sustain mitochondrial function, and how this can support mitochondrial homeostasis, especially in the distal parts of the neuron, to support neuronal activity.

Original languageEnglish
Pages (from-to)119-139
Number of pages21
JournalBiochemical Journal
Volume481
Issue number3
DOIs
StatePublished - Feb 2024

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