The role of growth factors in central nervous system tumours

Carsten Nieder, Juergen Schlegel, Nicolaus Andratschke, Reinhard Thamm, Anca L. Grosu, Michael Molls

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

The role of growth factors in tumour growth and progression has increasingly been studied over the last few years. This review summarizes the available data and discusses their limitations as well as their potential influence on future therapeutic strategies. A large body of data suggests an important role of EGF, TGF-β, PDGF and VEGF ligands and receptors in the vascularization of several brain tumour types, including gliomas and meningiomas. Recent experimental data indicate that inhibition of the signalling pathways may represent promising therapeutic strategies. Some inhibitory agents have now entered clinical trials, mainly for recurrent gliomas. Early results are presented.

Original languageEnglish
Pages (from-to)1681-1686
Number of pages6
JournalAnticancer Research
Volume23
Issue number2 C
StatePublished - Mar 2003

Keywords

  • Brain tumours
  • Glioblastoma multiforme
  • Glioma
  • Growth factors
  • Meningioma
  • Prognostic factors
  • Radiotherapy

Fingerprint

Dive into the research topics of 'The role of growth factors in central nervous system tumours'. Together they form a unique fingerprint.

Cite this