The role of exhaustion in CAR T cell therapy

Greg M. Delgoffe, Chenqi Xu, Crystal L. Mackall, Michael R. Green, Stephen Gottschalk, Daniel E. Speiser, Dietmar Zehn, Paul A. Beavis

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.

Original languageEnglish
Pages (from-to)885-888
Number of pages4
JournalCancer Cell
Volume39
Issue number7
DOIs
StatePublished - 12 Jul 2021

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