The role of exhaustion in CAR T cell therapy

Greg M. Delgoffe; Chenqi Xu; Crystal L. Mackall; Michael R. Green; Stephen Gottschalk; Daniel E. Speiser; Dietmar Zehn; Paul A. Beavis

doi:10.1016/j.ccell.2021.06.012

The role of exhaustion in CAR T cell therapy

Greg M. Delgoffe, Chenqi Xu, Crystal L. Mackall, Michael R. Green, Stephen Gottschalk, Daniel E. Speiser, Dietmar Zehn, Paul A. Beavis

Chair of Animal Physiology and Immunology

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.

Original language	English
Pages (from-to)	885-888
Number of pages	4
Journal	Cancer Cell
Volume	39
Issue number	7
DOIs	https://doi.org/10.1016/j.ccell.2021.06.012
State	Published - 12 Jul 2021

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10.1016/j.ccell.2021.06.012

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title = "The role of exhaustion in CAR T cell therapy",

abstract = "CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.",

author = "Delgoffe, {Greg M.} and Chenqi Xu and Mackall, {Crystal L.} and Green, {Michael R.} and Stephen Gottschalk and Speiser, {Daniel E.} and Dietmar Zehn and Beavis, {Paul A.}",

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AU - Delgoffe, Greg M.

AU - Xu, Chenqi

AU - Mackall, Crystal L.

AU - Green, Michael R.

AU - Gottschalk, Stephen

AU - Speiser, Daniel E.

AU - Zehn, Dietmar

AU - Beavis, Paul A.

PY - 2021/7/12

Y1 - 2021/7/12

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AB - CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.

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U2 - 10.1016/j.ccell.2021.06.012

DO - 10.1016/j.ccell.2021.06.012

M3 - Article

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AN - SCOPUS:85111605123

SN - 1535-6108

VL - 39

SP - 885

EP - 888

JO - Cancer Cell

JF - Cancer Cell

IS - 7

ER -

The role of exhaustion in CAR T cell therapy

Abstract

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