The role of claudin-6 in chromophobe renal cell carcinoma

Franziska Erlmeier; Stefanie Zschäbitz; Marie Mikuteit; Michael Autenrieth; Wilko Weichert; Arndt Hartmann; Sandra Steffens

doi:10.14670/HH-18-520

The role of claudin-6 in chromophobe renal cell carcinoma

Franziska Erlmeier, Stefanie Zschäbitz, Marie Mikuteit, Michael Autenrieth, Wilko Weichert, Arndt Hartmann, Sandra Steffens

Chair of Pathology

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1 Scopus citations

Abstract

Summary. Background. The prognostic value of Claudin-6 (CLDN6) in non clear cell renal cell carcinoma (RCC) is still unclear. Aim. To evaluate the prognostic impact of CLDN6 expression in a large cohort of chromophobe RCC (chRCC). Material and Methods. Patients who underwent renal surgery due to chRCC were recruited. Clinical data were retrospectively evaluated. Tumor specimens were analyzed for CLDN6 expression by immunohisto-chemistry. Results. 81 chRCC patients were eligible for analysis, thereof 10 (12.3%) patients were positive for CLDN6. No significant associations were found for CLDN6 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in overall survival (OS) for patients with CLDN6^- compared to CLDN6⁺ tumors (87.0% versus 62.5%; p=0.174). Conclusion. In chRCC CLDN6 expression is not associated with parameters of aggressiveness or survival. Due to the rare incidence of chRCC further studies with larger cohorts are warranted.

Original language	English
Pages (from-to)	403-407
Number of pages	5
Journal	Histology and Histopathology
Volume	38
Issue number	4
DOIs	https://doi.org/10.14670/HH-18-520
State	Published - Apr 2023

Keywords

Chromophobe histology
Claudin-6
Renal Cell Carcinoma
Survival

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title = "The role of claudin-6 in chromophobe renal cell carcinoma",

abstract = "Summary. Background. The prognostic value of Claudin-6 (CLDN6) in non clear cell renal cell carcinoma (RCC) is still unclear. Aim. To evaluate the prognostic impact of CLDN6 expression in a large cohort of chromophobe RCC (chRCC). Material and Methods. Patients who underwent renal surgery due to chRCC were recruited. Clinical data were retrospectively evaluated. Tumor specimens were analyzed for CLDN6 expression by immunohisto-chemistry. Results. 81 chRCC patients were eligible for analysis, thereof 10 (12.3%) patients were positive for CLDN6. No significant associations were found for CLDN6 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in overall survival (OS) for patients with CLDN6- compared to CLDN6+ tumors (87.0% versus 62.5%; p=0.174). Conclusion. In chRCC CLDN6 expression is not associated with parameters of aggressiveness or survival. Due to the rare incidence of chRCC further studies with larger cohorts are warranted.",

keywords = "Chromophobe histology, Claudin-6, Renal Cell Carcinoma, Survival",

author = "Franziska Erlmeier and Stefanie Zsch{\"a}bitz and Marie Mikuteit and Michael Autenrieth and Wilko Weichert and Arndt Hartmann and Sandra Steffens",

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year = "2023",

month = apr,

doi = "10.14670/HH-18-520",

language = "English",

volume = "38",

pages = "403--407",

journal = "Histology and Histopathology",

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T1 - The role of claudin-6 in chromophobe renal cell carcinoma

AU - Erlmeier, Franziska

AU - Zschäbitz, Stefanie

AU - Mikuteit, Marie

AU - Autenrieth, Michael

AU - Weichert, Wilko

AU - Hartmann, Arndt

AU - Steffens, Sandra

N1 - Publisher Copyright: ©The Author(s) 2022.

PY - 2023/4

Y1 - 2023/4

N2 - Summary. Background. The prognostic value of Claudin-6 (CLDN6) in non clear cell renal cell carcinoma (RCC) is still unclear. Aim. To evaluate the prognostic impact of CLDN6 expression in a large cohort of chromophobe RCC (chRCC). Material and Methods. Patients who underwent renal surgery due to chRCC were recruited. Clinical data were retrospectively evaluated. Tumor specimens were analyzed for CLDN6 expression by immunohisto-chemistry. Results. 81 chRCC patients were eligible for analysis, thereof 10 (12.3%) patients were positive for CLDN6. No significant associations were found for CLDN6 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in overall survival (OS) for patients with CLDN6- compared to CLDN6+ tumors (87.0% versus 62.5%; p=0.174). Conclusion. In chRCC CLDN6 expression is not associated with parameters of aggressiveness or survival. Due to the rare incidence of chRCC further studies with larger cohorts are warranted.

AB - Summary. Background. The prognostic value of Claudin-6 (CLDN6) in non clear cell renal cell carcinoma (RCC) is still unclear. Aim. To evaluate the prognostic impact of CLDN6 expression in a large cohort of chromophobe RCC (chRCC). Material and Methods. Patients who underwent renal surgery due to chRCC were recruited. Clinical data were retrospectively evaluated. Tumor specimens were analyzed for CLDN6 expression by immunohisto-chemistry. Results. 81 chRCC patients were eligible for analysis, thereof 10 (12.3%) patients were positive for CLDN6. No significant associations were found for CLDN6 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in overall survival (OS) for patients with CLDN6- compared to CLDN6+ tumors (87.0% versus 62.5%; p=0.174). Conclusion. In chRCC CLDN6 expression is not associated with parameters of aggressiveness or survival. Due to the rare incidence of chRCC further studies with larger cohorts are warranted.

KW - Chromophobe histology

KW - Claudin-6

KW - Renal Cell Carcinoma

KW - Survival

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DO - 10.14670/HH-18-520

M3 - Article

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AN - SCOPUS:85151573765

SN - 0213-3911

VL - 38

SP - 403

EP - 407

JO - Histology and Histopathology

JF - Histology and Histopathology

IS - 4

ER -

The role of claudin-6 in chromophobe renal cell carcinoma

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