The restless legs syndrome - A genetic view of the disease

Juliane Winkelman; Karin Eckard; Bertram Müller-Myshok; Thomas Gasser; Claudia Trenkwalder

doi:10.1046/j.1439-054x.2002.02174.x

The restless legs syndrome - A genetic view of the disease

Juliane Winkelman, Karin Eckard, Bertram Müller-Myshok, Thomas Gasser, Claudia Trenkwalder

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Although the symptoms of RLS have been known since centuries it was only in 1995 that common diagnostic criteria have been drawn up. Population based studies conducted a high prevalence of up to 10 % in the elderly. Up to 60 % of the patients report a positive family history. However, no gene has been mapped so far. A study on the underlying genetic model in a German population suggested an autosomal dominant mode of inheritance in early age-at-onset families. Only recently a susceptibility locus has been mapped in the French canadian population on chromosome 12.

Original language	English
Pages (from-to)	3-6
Number of pages	4
Journal	Somnologie
Volume	6
Issue number	1
DOIs	https://doi.org/10.1046/j.1439-054x.2002.02174.x
State	Published - 2002
Externally published	Yes

Keywords

Familial
Genetics
Restless legs syndrome
Sleep

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10.1046/j.1439-054x.2002.02174.x

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AU - Eckard, Karin

AU - Müller-Myshok, Bertram

AU - Gasser, Thomas

AU - Trenkwalder, Claudia

PY - 2002

Y1 - 2002

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AB - Although the symptoms of RLS have been known since centuries it was only in 1995 that common diagnostic criteria have been drawn up. Population based studies conducted a high prevalence of up to 10 % in the elderly. Up to 60 % of the patients report a positive family history. However, no gene has been mapped so far. A study on the underlying genetic model in a German population suggested an autosomal dominant mode of inheritance in early age-at-onset families. Only recently a susceptibility locus has been mapped in the French canadian population on chromosome 12.

KW - Familial

KW - Genetics

KW - Restless legs syndrome

KW - Sleep

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DO - 10.1046/j.1439-054x.2002.02174.x

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JO - Somnologie

JF - Somnologie

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ER -

The restless legs syndrome - A genetic view of the disease

Abstract

Keywords

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