TY - JOUR
T1 - The ReCoDe addiction research consortium
T2 - Losing and regaining control over drug intake—Findings and future perspectives
AU - Other members of the ReCoDe Consortium
AU - Spanagel, Rainer
AU - Bach, Patrick
AU - Banaschewski, Tobias
AU - Beck, Anne
AU - Bermpohl, Felix
AU - Bernardi, Rick E.
AU - Beste, Christian
AU - Deserno, Lorenz
AU - Durstewitz, Daniel
AU - Ebner-Priemer, Ulrich
AU - Endrass, Tanja
AU - Ersche, Karen D.
AU - Feld, Gordon
AU - Gerchen, Martin Fungisai
AU - Gerlach, Björn
AU - Goschke, Thomas
AU - Hansson, Anita Christiane
AU - Heim, Christine
AU - Kiebel, Stefan
AU - Kiefer, Falk
AU - Kirsch, Peter
AU - Kirschbaum, Clemens
AU - Koppe, Georgia
AU - Lenz, Bernd
AU - Liu, Shuyan
AU - Marxen, Michael
AU - Meinhardt, Marcus W.
AU - Meyer-Lindenberg, Andreas
AU - Montag, Christiane
AU - Müller, Christian P.
AU - Nagel, Wolfgang E.
AU - Oliveria, Ana M.M.
AU - Owald, David
AU - Pilhatsch, Maximilian
AU - Priller, Josef
AU - Rapp, Michael A.
AU - Reichert, Markus
AU - Ripke, Stephan
AU - Ritter, Kerstin
AU - Romanczuk-Seiferth, Nina
AU - Schlagenhauf, Florian
AU - Schwarz, Emanuel
AU - Schwöbel, Sarah
AU - Smolka, Michael N.
AU - Soekadar, Surjo R.
AU - Sommer, Wolfgang H.
AU - Stock, Ann Kathrin
AU - Ströhle, Andreas
AU - Tost, Heike
AU - Vollstädt-Klein, Sabine
N1 - Publisher Copyright:
© 2024 The Author(s). Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
PY - 2024/7
Y1 - 2024/7
N2 - Substance use disorders (SUDs) are seen as a continuum ranging from goal-directed and hedonic drug use to loss of control over drug intake with aversive consequences for mental and physical health and social functioning. The main goals of our interdisciplinary German collaborative research centre on Losing and Regaining Control over Drug Intake (ReCoDe) are (i) to study triggers (drug cues, stressors, drug priming) and modifying factors (age, gender, physical activity, cognitive functions, childhood adversity, social factors, such as loneliness and social contact/interaction) that longitudinally modulate the trajectories of losing and regaining control over drug consumption under real-life conditions. (ii) To study underlying behavioural, cognitive and neurobiological mechanisms of disease trajectories and drug-related behaviours and (iii) to provide non-invasive mechanism-based interventions. These goals are achieved by: (A) using innovative mHealth (mobile health) tools to longitudinally monitor the effects of triggers and modifying factors on drug consumption patterns in real life in a cohort of 900 patients with alcohol use disorder. This approach will be complemented by animal models of addiction with 24/7 automated behavioural monitoring across an entire disease trajectory; i.e. from a naïve state to a drug-taking state to an addiction or resilience-like state. (B) The identification and, if applicable, computational modelling of key molecular, neurobiological and psychological mechanisms (e.g., reduced cognitive flexibility) mediating the effects of such triggers and modifying factors on disease trajectories. (C) Developing and testing non-invasive interventions (e.g., Just-In-Time-Adaptive-Interventions (JITAIs), various non-invasive brain stimulations (NIBS), individualized physical activity) that specifically target the underlying mechanisms for regaining control over drug intake. Here, we will report on the most important results of the first funding period and outline our future research strategy.
AB - Substance use disorders (SUDs) are seen as a continuum ranging from goal-directed and hedonic drug use to loss of control over drug intake with aversive consequences for mental and physical health and social functioning. The main goals of our interdisciplinary German collaborative research centre on Losing and Regaining Control over Drug Intake (ReCoDe) are (i) to study triggers (drug cues, stressors, drug priming) and modifying factors (age, gender, physical activity, cognitive functions, childhood adversity, social factors, such as loneliness and social contact/interaction) that longitudinally modulate the trajectories of losing and regaining control over drug consumption under real-life conditions. (ii) To study underlying behavioural, cognitive and neurobiological mechanisms of disease trajectories and drug-related behaviours and (iii) to provide non-invasive mechanism-based interventions. These goals are achieved by: (A) using innovative mHealth (mobile health) tools to longitudinally monitor the effects of triggers and modifying factors on drug consumption patterns in real life in a cohort of 900 patients with alcohol use disorder. This approach will be complemented by animal models of addiction with 24/7 automated behavioural monitoring across an entire disease trajectory; i.e. from a naïve state to a drug-taking state to an addiction or resilience-like state. (B) The identification and, if applicable, computational modelling of key molecular, neurobiological and psychological mechanisms (e.g., reduced cognitive flexibility) mediating the effects of such triggers and modifying factors on disease trajectories. (C) Developing and testing non-invasive interventions (e.g., Just-In-Time-Adaptive-Interventions (JITAIs), various non-invasive brain stimulations (NIBS), individualized physical activity) that specifically target the underlying mechanisms for regaining control over drug intake. Here, we will report on the most important results of the first funding period and outline our future research strategy.
KW - addiction
KW - alcohol
KW - alternative rewards
KW - ambulatory assessment (AA)
KW - animal models
KW - behavioural control
KW - cocaine
KW - cognitive control
KW - computational models
KW - craving
KW - decision-making
KW - ecological momentary assessment (EMA)
KW - habit formation
KW - relapse
KW - tobacco
UR - http://www.scopus.com/inward/record.url?scp=85197276995&partnerID=8YFLogxK
U2 - 10.1111/adb.13419
DO - 10.1111/adb.13419
M3 - Review article
AN - SCOPUS:85197276995
SN - 1355-6215
VL - 29
JO - Addiction Biology
JF - Addiction Biology
IS - 7
M1 - e13419
ER -