TY - JOUR
T1 - The rationale and design of the Giant Intracranial Aneurysm Registry
T2 - A retrospective and prospective study
AU - Dengler, Julius
AU - Heuschmann, Peter U.
AU - Endres, Matthias
AU - Meyer, Bernhard
AU - Rohde, Veit
AU - Rufenacht, Daniel A.
AU - Vajkoczy, Peter
PY - 2011/6
Y1 - 2011/6
N2 - Aims and Hypothesis Giant intracranial aneurysms have a poor prognosis mainly due to their high risk of rupture. Because their incidence is low, clinical trial evidence for adequate treatment is lacking. The Giant Intracranial Aneurysm Registry is designed to document current treatment strategies in giant aneurysm care and to monitor the course of the disease over five-years. It aims to evaluate the hypothesis that all three possible branches of therapy (conservative/endovascular/surgical) lead to equal rupture rates. Design The Giant Intracranial Aneurysm Registry is an interdisciplinary multicenter observational study. Each center recruits patients diagnosed with a giant intracranial aneurysm both prospectively and retrospectively. Primary outcome will be the aneurysm rupture rate at five-years of follow-up. Study Outcome Patient enrollment has begun at 20 neurovascular centers throughout Germany, with 19 further centers applying for local ethics approval to take part in the study. The first nine months are designed as a pilot phase followed by the integration of study centers throughout the EU and the initiation of separate sub-studies. Discussion Giant intracranial aneurysms have often been ignored or marginalized due to their low incidence. The Giant Intracranial Aneurysm Registry aims to lead to a better understanding of these complex lesions and to serve as a basis for the development of future clinical studies.
AB - Aims and Hypothesis Giant intracranial aneurysms have a poor prognosis mainly due to their high risk of rupture. Because their incidence is low, clinical trial evidence for adequate treatment is lacking. The Giant Intracranial Aneurysm Registry is designed to document current treatment strategies in giant aneurysm care and to monitor the course of the disease over five-years. It aims to evaluate the hypothesis that all three possible branches of therapy (conservative/endovascular/surgical) lead to equal rupture rates. Design The Giant Intracranial Aneurysm Registry is an interdisciplinary multicenter observational study. Each center recruits patients diagnosed with a giant intracranial aneurysm both prospectively and retrospectively. Primary outcome will be the aneurysm rupture rate at five-years of follow-up. Study Outcome Patient enrollment has begun at 20 neurovascular centers throughout Germany, with 19 further centers applying for local ethics approval to take part in the study. The first nine months are designed as a pilot phase followed by the integration of study centers throughout the EU and the initiation of separate sub-studies. Discussion Giant intracranial aneurysms have often been ignored or marginalized due to their low incidence. The Giant Intracranial Aneurysm Registry aims to lead to a better understanding of these complex lesions and to serve as a basis for the development of future clinical studies.
KW - Cerebral revascularization
KW - Clipping
KW - Coiling
KW - Giant Intracranial Aneurysm Registry
KW - Giant intracranial aneurysm
KW - SAH
UR - http://www.scopus.com/inward/record.url?scp=79955785193&partnerID=8YFLogxK
U2 - 10.1111/j.1747-4949.2011.00588.x
DO - 10.1111/j.1747-4949.2011.00588.x
M3 - Article
C2 - 21557815
AN - SCOPUS:79955785193
SN - 1747-4930
VL - 6
SP - 266
EP - 270
JO - International Journal of Stroke
JF - International Journal of Stroke
IS - 3
ER -