The RamA regulon: complex regulatory interactions in relation to central metabolism in Corynebacterium glutamicum

Adnan Shah, Bastian Blombach, Rahul Gauttam, Bernhard J. Eikmanns

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Corynebacterium glutamicum is an industrial workhorse used for the production of amino acids and a variety of other chemicals and fuels. Within its regulatory repertoire, C. glutamicum possesses RamA which was initially identified as essential transcriptional regulator of acetate metabolism. Further studies revealed its relevance for ethanol and propionate catabolism and also identified RamA to function as global regulator in the metabolism of C. glutamicum. Thereby, RamA acts as transcriptional activator or repressor of genes encoding enzymes which are involved in carbon uptake, central carbon metabolism, and cell wall synthesis. RamA controls the expression of target genes either directly and/or indirectly by constituting feed-forward loop type of transcriptional motifs with other regulators such as GlxR, SugR, RamB, and GntR1. In this review, we summarize the current knowledge on RamA, its regulon, and its regulatory interplay with other transcriptional regulators coordinating the metabolism of C. glutamicum.

Original languageEnglish
Pages (from-to)5901-5910
Number of pages10
JournalApplied Microbiology and Biotechnology
Volume102
Issue number14
DOIs
StatePublished - 1 Jul 2018
Externally publishedYes

Keywords

  • Central metabolism
  • Corynebacterium glutamicum
  • Regulator of acetate metabolism RamA

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