The prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status

Martin Kruschewski; Kathrin Mueller; Sybille Lipka; Jan Budczies; Aurelia Noske; Heinz Johannes Buhr; Sefer Elezkurtaj

doi:10.3390/cancers3011274

The prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status

Martin Kruschewski, Kathrin Mueller, Sybille Lipka, Jan Budczies, Aurelia Noske, Heinz Johannes Buhr, Sefer Elezkurtaj

Charité – Universitätsmedizin Berlin

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The prognostic value of p53 and p21 expression in colorectal cancer is still under debate. We hypothesize that the prognostic impact of p53 expression is dependent on p21 status. The expression of p53 and p21 was immunohistochemically investigated in a prospective cohort of 116 patients with UICC stage II and III sporadic colorectal cancer. The results were correlated with overall and recurrence-free survival. The mean observation period was 51.8 ± 2.5 months. Expression of p53 was observed in 72 tumors (63%). Overall survival was significantly better in patients with p53-positive carcinomas than in those without p53 expression (p = 0.048). No differences were found in recurrence-free survival (p = 0.161). The p53+/p21- combination was seen in 68% (n = 49), the p53+/p21+ combination in 32% (n = 23). Patients with p53+/p21- carcinomas had significantly better overall and recurrence-free survival than those with p53+/p21+ (p < 0.0001 resp. p = 0.003). Our data suggest that the prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status.

Original language	English
Pages (from-to)	1274-1284
Number of pages	11
Journal	Cancers
Volume	3
Issue number	1
DOIs	https://doi.org/10.3390/cancers3011274
State	Published - Mar 2011
Externally published	Yes

Keywords

Colorectal cancer
Prognosis
p21
p53

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10.3390/cancers3011274

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title = "The prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status",

abstract = "The prognostic value of p53 and p21 expression in colorectal cancer is still under debate. We hypothesize that the prognostic impact of p53 expression is dependent on p21 status. The expression of p53 and p21 was immunohistochemically investigated in a prospective cohort of 116 patients with UICC stage II and III sporadic colorectal cancer. The results were correlated with overall and recurrence-free survival. The mean observation period was 51.8 ± 2.5 months. Expression of p53 was observed in 72 tumors (63%). Overall survival was significantly better in patients with p53-positive carcinomas than in those without p53 expression (p = 0.048). No differences were found in recurrence-free survival (p = 0.161). The p53+/p21- combination was seen in 68% (n = 49), the p53+/p21+ combination in 32% (n = 23). Patients with p53+/p21- carcinomas had significantly better overall and recurrence-free survival than those with p53+/p21+ (p < 0.0001 resp. p = 0.003). Our data suggest that the prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status.",

keywords = "Colorectal cancer, Prognosis, p21, p53",

author = "Martin Kruschewski and Kathrin Mueller and Sybille Lipka and Jan Budczies and Aurelia Noske and Buhr, {Heinz Johannes} and Sefer Elezkurtaj",

year = "2011",

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doi = "10.3390/cancers3011274",

language = "English",

volume = "3",

pages = "1274--1284",

journal = "Cancers",

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TY - JOUR

T1 - The prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status

AU - Kruschewski, Martin

AU - Mueller, Kathrin

AU - Lipka, Sybille

AU - Budczies, Jan

AU - Noske, Aurelia

AU - Buhr, Heinz Johannes

AU - Elezkurtaj, Sefer

PY - 2011/3

Y1 - 2011/3

N2 - The prognostic value of p53 and p21 expression in colorectal cancer is still under debate. We hypothesize that the prognostic impact of p53 expression is dependent on p21 status. The expression of p53 and p21 was immunohistochemically investigated in a prospective cohort of 116 patients with UICC stage II and III sporadic colorectal cancer. The results were correlated with overall and recurrence-free survival. The mean observation period was 51.8 ± 2.5 months. Expression of p53 was observed in 72 tumors (63%). Overall survival was significantly better in patients with p53-positive carcinomas than in those without p53 expression (p = 0.048). No differences were found in recurrence-free survival (p = 0.161). The p53+/p21- combination was seen in 68% (n = 49), the p53+/p21+ combination in 32% (n = 23). Patients with p53+/p21- carcinomas had significantly better overall and recurrence-free survival than those with p53+/p21+ (p < 0.0001 resp. p = 0.003). Our data suggest that the prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status.

AB - The prognostic value of p53 and p21 expression in colorectal cancer is still under debate. We hypothesize that the prognostic impact of p53 expression is dependent on p21 status. The expression of p53 and p21 was immunohistochemically investigated in a prospective cohort of 116 patients with UICC stage II and III sporadic colorectal cancer. The results were correlated with overall and recurrence-free survival. The mean observation period was 51.8 ± 2.5 months. Expression of p53 was observed in 72 tumors (63%). Overall survival was significantly better in patients with p53-positive carcinomas than in those without p53 expression (p = 0.048). No differences were found in recurrence-free survival (p = 0.161). The p53+/p21- combination was seen in 68% (n = 49), the p53+/p21+ combination in 32% (n = 23). Patients with p53+/p21- carcinomas had significantly better overall and recurrence-free survival than those with p53+/p21+ (p < 0.0001 resp. p = 0.003). Our data suggest that the prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status.

KW - Colorectal cancer

KW - Prognosis

KW - p21

KW - p53

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U2 - 10.3390/cancers3011274

DO - 10.3390/cancers3011274

M3 - Article

AN - SCOPUS:79953699976

SN - 2072-6694

VL - 3

SP - 1274

EP - 1284

JO - Cancers

JF - Cancers

IS - 1

ER -

The prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status

Abstract

Keywords

UN SDGs

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