The PI3K pathway in B cell metabolism

Julia Jellusova, Robert C. Rickert

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations

Abstract

B cell growth and proliferation is tightly regulated by signaling through the B cell receptor and by other membrane bound receptors responding to different cytokines. The PI3K signaling pathway has been shown to play a crucial role in B cell activation, differentiation and survival. Activated B cells undergo metabolic reprograming in response to changing energetic and biosynthetic demands. B cells also need to be able to coordinate metabolic activity and proliferation with nutrient availability. The PI3K signaling network has been implicated in regulating nutrient acquisition, utilization and biosynthesis, thus integrating receptor-mediated signaling with cell metabolism. In this review, we discuss the current knowledge about metabolic changes induced in activated B cells, strategies to adapt to metabolic stress and the role of PI3K signaling in these processes.

Original languageEnglish
Pages (from-to)359-378
Number of pages20
JournalCritical Reviews in Biochemistry and Molecular Biology
Volume51
Issue number5
DOIs
StatePublished - 2 Sep 2016
Externally publishedYes

Keywords

  • Akt
  • glycolysis
  • lymphocyte
  • mTOR
  • mitochondria

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