TY - JOUR
T1 - The overnight reduction of amyloid β 1-42 plasma levels is diminished by the extent of sleep fragmentation, sAPP-β, and APOE ε4 in psychiatrists on call
AU - Grimmer, Timo
AU - Laub, Theresa
AU - Hapfelmeier, Alexander
AU - Eisele, Tamara
AU - Fatke, Bastian
AU - Hölzle, Patricia
AU - Lüscher, Sandra
AU - Parchmann, Anna Mareike
AU - Rentrop, Michael
AU - Schwerthöffer, Dirk
AU - Müller-Sarnowski, Felix
AU - Ortner, Marion
AU - Goldhardt, Oliver
AU - Kurz, Alexander
AU - Förstl, Hans
AU - Alexopoulos, Panagiotis
N1 - Publisher Copyright:
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Introduction: In mice there might be an association between sleep deprivation and amyloid β plasma levels. Hence, we examined whether amyloid plasma levels are associated with sleep duration or fragmentation in 17 psychiatrists on-call. Methods: Amyloid β (Aβ)42, Aβ40, and soluble amyloid precursor protein β (sAPP-β) plasma concentrations were measured at the beginning and end of 90 on-call nights, and analyzed using generalized linear models. Results: In on-call nights, a 10.7% reduction of Aβ42 was revealed overnight. Every single short sleep interruption diminished this reduction by 5.4%, as well as every pg/mL of sAPP-β by 1.2%, each copy of APOE ε4 by 10.6%, and each year of professional experience by 3.0%. Discussion: The extent of sleep fragmentation diminishes the physiological overnight reduction of Aβ42 but not Aβ40 plasma levels in the same direction as the enzyme for Aβ42 production, the genetic risk factor for Alzheimer's disease (AD), and on-call experience. Might on-call duty and sleep fragmentation in general alter the risk for AD?.
AB - Introduction: In mice there might be an association between sleep deprivation and amyloid β plasma levels. Hence, we examined whether amyloid plasma levels are associated with sleep duration or fragmentation in 17 psychiatrists on-call. Methods: Amyloid β (Aβ)42, Aβ40, and soluble amyloid precursor protein β (sAPP-β) plasma concentrations were measured at the beginning and end of 90 on-call nights, and analyzed using generalized linear models. Results: In on-call nights, a 10.7% reduction of Aβ42 was revealed overnight. Every single short sleep interruption diminished this reduction by 5.4%, as well as every pg/mL of sAPP-β by 1.2%, each copy of APOE ε4 by 10.6%, and each year of professional experience by 3.0%. Discussion: The extent of sleep fragmentation diminishes the physiological overnight reduction of Aβ42 but not Aβ40 plasma levels in the same direction as the enzyme for Aβ42 production, the genetic risk factor for Alzheimer's disease (AD), and on-call experience. Might on-call duty and sleep fragmentation in general alter the risk for AD?.
KW - Alzheimer's disease
KW - amyloid plasma levels
KW - on-call duty
KW - psychiatrists
KW - sleep
KW - sleep fragmentation
UR - http://www.scopus.com/inward/record.url?scp=85083069931&partnerID=8YFLogxK
U2 - 10.1002/alz.12072
DO - 10.1002/alz.12072
M3 - Article
C2 - 32270596
AN - SCOPUS:85083069931
SN - 1552-5260
VL - 16
SP - 759
EP - 769
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 5
ER -