The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity

Jérôme Clerc, Nan Li, Daniel Krahn, Michael Groll, André S. Bachmann, Bogdan I. Florea, Herman S. Overkleeft, Markus Kaiser

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The preparation of a Syringolin A/Glidobactin A hybrid (SylA-GlbA) consisting of a SylA macrocycle connected to the GlbA side chain and its potent proteasome targeting of all three proteasomal subsites is reported. The influence of the syrbactin macrocycle moiety on subsite selectivity is demonstrated.

Original languageEnglish
Pages (from-to)385-387
Number of pages3
JournalChemical Communications
Volume47
Issue number1
DOIs
StatePublished - 6 Dec 2011

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