The Metastable XBP1u Transmembrane Domain Defines Determinants for Intramembrane Proteolysis by Signal Peptide Peptidase

Keyphrases

• Transmembrane Domain 100%
• Signal Peptidase 100%
• Intramembrane Proteolysis 100%
• XBP1u 100%
• Endoplasmic Reticulum 40%
• Unfolded Protein Response 40%
• X-box Binding Protein 1 (XBP1) 40%
• Automated Algorithm 20%
• Transcription Factor 20%
• Peptide Bond 20%
• Exchange Kinetics 20%
• Cell-free 20%
• Conformational Flexibility 20%
• Degradation Pathway 20%
• Mutagenesis 20%
• Enzyme Active Site 20%
• Membrane Association 20%
• Side Chain Interactions 20%
• Response Activation 20%
• Transmembrane Helix 20%
• Translocation Assay 20%
• Transmembrane Helix Dynamics 20%
• Amide Exchange 20%
• Endoplasmic Reticulum-associated Degradation 20%
• Transmembrane Region 20%
• Cellular Assay 20%
• Overactivation 20%
• Ribosome-nascent Chain Complex 20%

Biochemistry, Genetics and Molecular Biology

• Transmembrane Domain 100%
• Signal Peptide Peptidase 100%
• Proteolysis 100%
• Unfolded Protein Response 66%
• Messenger RNA 66%
• Dynamics 33%
• Endoplasmic-Reticulum-Associated Protein Degradation 33%
• Mutagenesis 33%
• XBP1 33%
• Endoplasmic Reticulum Membrane 33%
• Enzyme Active Site 33%
• Peptide Bond 33%
• X Box Binding Protein 1 33%