The membrane-bound aspartyl protease BACE1: Molecular and functional properties in Alzheimer's disease and beyond

Keyphrases

• Alzheimer's Disease 100%
• Functional Properties 100%
• Molecular Properties 100%
• Membrane Binding 100%
• Aspartic Protease 100%
• β-site APP-cleaving Enzyme 1 (BACE1) 100%
• Gene-deficient Mice 11%
• Mechanism-based 11%
• Peripheral Nervous System 11%
• Lipids 11%
• Protease 11%
• Transmembrane 11%
• Physiological Processes 11%
• Enzymatic Properties 11%
• Drug Target 11%
• Cell Properties 11%
• Therapeutic Inhibitors 11%
• Myelination 11%
• Neuregulin-1 (NRG1) 11%
• Amyloid-β Peptide 11%
• Physiological Consequences 11%
• Alzheimer's Disease Pathology 11%
• BACE1 Substrates 11%
• Translational Mechanism 11%
• New Phenotypes 11%

Biochemistry, Genetics and Molecular Biology

• Protease 100%
• Aspartic Acid 100%
• Lipid 33%
• Neuregulin 1 33%
• Enzyme 33%
• Myelination 33%
• Physiological Process 33%
• Amyloid Protein 33%