The inhibition of human neuronal K+ currents by general anesthetic agents is altered by extracellular K+

Patrick Friederich; Bernd W. Urban

doi:10.1016/S0169-328X(98)00209-5

The inhibition of human neuronal K⁺ currents by general anesthetic agents is altered by extracellular K⁺

Patrick Friederich, Bernd W. Urban

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We demonstrate for the first time that the extracellular potassium concentration influences the inhibition of human neuronal delayed rectifier potassium currents by general anesthetics. This observation suggests a modulatory role for extracellular potassium ions in the action of some general anesthetic agents.

Original language	English
Pages (from-to)	301-304
Number of pages	4
Journal	Molecular Brain Research
Volume	60
Issue number	2
DOIs	https://doi.org/10.1016/S0169-328X(98)00209-5
State	Published - 1 Oct 1998
Externally published	Yes

Keywords

Anesthetic mechanisms
Etomidate
Extracellular concentration
Human neuronal
Intravenous anesthetic
Ketamine
Patch-clamp-technique
Potassium
Potassium current
Propofol
Whole cell

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10.1016/S0169-328X(98)00209-5

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title = "The inhibition of human neuronal K+ currents by general anesthetic agents is altered by extracellular K+",

abstract = "We demonstrate for the first time that the extracellular potassium concentration influences the inhibition of human neuronal delayed rectifier potassium currents by general anesthetics. This observation suggests a modulatory role for extracellular potassium ions in the action of some general anesthetic agents.",

keywords = "Anesthetic mechanisms, Etomidate, Extracellular concentration, Human neuronal, Intravenous anesthetic, Ketamine, Patch-clamp-technique, Potassium, Potassium current, Propofol, Whole cell",

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KW - Ketamine

KW - Patch-clamp-technique

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KW - Potassium current

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The inhibition of human neuronal K⁺ currents by general anesthetic agents is altered by extracellular K⁺

Abstract

Keywords

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