The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study

Paolo Bosco; Alberto Redolfi; Martina Bocchetta; Clarissa Ferrari; Anna Mega; Samantha Galluzzi; Mark Austin; Andrea Chincarini; D. Louis Collins; Simon Duchesne; Bénédicte Maréchal; Alexis Roche; Francesco Sensi; Robin Wolz; Montserrat Alegret; Frederic Assal; Mircea Balasa; Christine Bastin; Anastasia Bougea; Derya Durusu Emek-Savaş; Sebastiaan Engelborghs; Timo Grimmer; Galina Grosu; Milica G. Kramberger; Brian Lawlor; Gorana Mandic Stojmenovic; Mihaela Marinescu; Patrizia Mecocci; José Luis Molinuevo; Ricardo Morais; Ellis Niemantsverdriet; Flavio Nobili; Konstantinos Ntovas; Sarah O'Dwyer; George P. Paraskevas; Luca Pelini; Agnese Picco; Eric Salmon; Isabel Santana; Oscar Sotolongo-Grau; Luiza Spiru; Elka Stefanova; Katarina Surlan Popovic; Magda Tsolaki; Görsev G. Yener; Dina Zekry; Giovanni B. Frisoni

doi:10.1016/j.jalz.2017.01.019

The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study

Paolo Bosco
, Alberto Redolfi
, Martina Bocchetta
, Clarissa Ferrari
, Anna Mega
, Samantha Galluzzi
, Mark Austin
, Andrea Chincarini
, D. Louis Collins
, Simon Duchesne
, Bénédicte Maréchal
, Alexis Roche
, Francesco Sensi
, Robin Wolz
, Montserrat Alegret
, Frederic Assal
, Mircea Balasa
, Christine Bastin
, Anastasia Bougea
, Derya Durusu Emek-Savaş

Sebastiaan Engelborghs, Timo Grimmer, Galina Grosu, Milica G. Kramberger, Brian Lawlor, Gorana Mandic Stojmenovic, Mihaela Marinescu, Patrizia Mecocci, José Luis Molinuevo, Ricardo Morais, Ellis Niemantsverdriet, Flavio Nobili, Konstantinos Ntovas, Sarah O'Dwyer, George P. Paraskevas, Luca Pelini, Agnese Picco, Eric Salmon, Isabel Santana, Oscar Sotolongo-Grau, Luiza Spiru, Elka Stefanova, Katarina Surlan Popovic, Magda Tsolaki, Görsev G. Yener, Dina Zekry, Giovanni B. Frisoni

Department of Psychiatry and Psychotherapy

IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli
University College London
IXICO plc
Sezione INFN di Genova
McGill University
True Positive Medical Devices Inc.
Siemens Healthcare AG
Centre Hospitalier Universitaire Vaudois
EPFL
Institut Català de Neurociències Aplicades
University of Geneva
Hospital Clinic Barcelona
University of Liège
National and Kapodistrian University of Athens
Dokuz Eylul University Health Campus
University of Antwerp
Hospital Network Antwerp (ZNA) Hoge Beuken and Middelheim
Elias University
University Medical Centre Ljubljana
St James's Hospital
CCS
Università di Perugia
Hospital Universitàrio de Coimbra
IRCCS for Cancer Research
Aristotle University of Thessaloniki
Central Military Emergency University Hospital
Ana Aslan International Foundation
University of Belgrade

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Introduction Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear. Methods Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini–Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed. Results An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of −8.0% (95% credible interval: [−11.5, −5.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, ¹⁸F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (−8.5, CrI: [−11.5, −5.6]; −14.1, CrI: [−19.3, −8.8]; −10.6, CrI: [−14.6, −6.1], respectively). Discussion There is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup.

Original language	English
Pages (from-to)	1013-1023
Number of pages	11
Journal	Alzheimer's and Dementia
Volume	13
Issue number	9
DOIs	https://doi.org/10.1016/j.jalz.2017.01.019
State	Published - Sep 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alzheimer's disease
Biomarkers
Diagnostic confidence of AD
Hippocampal volume
Medial temporal lobe atrophy

Access to Document

10.1016/j.jalz.2017.01.019

Cite this

Bosco, P., Redolfi, A., Bocchetta, M., Ferrari, C., Mega, A., Galluzzi, S., Austin, M., Chincarini, A., Collins, D. L., Duchesne, S., Maréchal, B., Roche, A., Sensi, F., Wolz, R., Alegret, M., Assal, F., Balasa, M., Bastin, C., Bougea, A., ... Frisoni, G. B. (2017). The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study. Alzheimer's and Dementia, 13(9), 1013-1023. https://doi.org/10.1016/j.jalz.2017.01.019

@article{048e34bee49c41e3baacc26cb6146f0c,

title = "The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study",

abstract = "Introduction Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear. Methods Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini–Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed. Results An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of −8.0\% (95\% credible interval: [−11.5, −5.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, 18F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (−8.5, CrI: [−11.5, −5.6]; −14.1, CrI: [−19.3, −8.8]; −10.6, CrI: [−14.6, −6.1], respectively). Discussion There is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup.",

keywords = "Alzheimer's disease, Biomarkers, Diagnostic confidence of AD, Hippocampal volume, Medial temporal lobe atrophy",

author = "Paolo Bosco and Alberto Redolfi and Martina Bocchetta and Clarissa Ferrari and Anna Mega and Samantha Galluzzi and Mark Austin and Andrea Chincarini and Collins, \{D. Louis\} and Simon Duchesne and B{\'e}n{\'e}dicte Mar{\'e}chal and Alexis Roche and Francesco Sensi and Robin Wolz and Montserrat Alegret and Frederic Assal and Mircea Balasa and Christine Bastin and Anastasia Bougea and Emek-Sava{\c s}, \{Derya Durusu\} and Sebastiaan Engelborghs and Timo Grimmer and Galina Grosu and Kramberger, \{Milica G.\} and Brian Lawlor and \{Mandic Stojmenovic\}, Gorana and Mihaela Marinescu and Patrizia Mecocci and Molinuevo, \{Jos{\'e} Luis\} and Ricardo Morais and Ellis Niemantsverdriet and Flavio Nobili and Konstantinos Ntovas and Sarah O'Dwyer and Paraskevas, \{George P.\} and Luca Pelini and Agnese Picco and Eric Salmon and Isabel Santana and Oscar Sotolongo-Grau and Luiza Spiru and Elka Stefanova and Popovic, \{Katarina Surlan\} and Magda Tsolaki and Yener, \{G{\"o}rsev G.\} and Dina Zekry and Frisoni, \{Giovanni B.\}",

note = "Publisher Copyright: {\textcopyright} 2017 the Alzheimer's Association",

year = "2017",

month = sep,

doi = "10.1016/j.jalz.2017.01.019",

language = "English",

volume = "13",

pages = "1013--1023",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley and Sons Inc.",

number = "9",

}

Bosco, P, Redolfi, A, Bocchetta, M, Ferrari, C, Mega, A, Galluzzi, S, Austin, M, Chincarini, A, Collins, DL, Duchesne, S, Maréchal, B, Roche, A, Sensi, F, Wolz, R, Alegret, M, Assal, F, Balasa, M, Bastin, C, Bougea, A, Emek-Savaş, DD, Engelborghs, S, Grimmer, T, Grosu, G, Kramberger, MG, Lawlor, B, Mandic Stojmenovic, G, Marinescu, M, Mecocci, P, Molinuevo, JL, Morais, R, Niemantsverdriet, E, Nobili, F, Ntovas, K, O'Dwyer, S, Paraskevas, GP, Pelini, L, Picco, A, Salmon, E, Santana, I, Sotolongo-Grau, O, Spiru, L, Stefanova, E, Popovic, KS, Tsolaki, M, Yener, GG, Zekry, D & Frisoni, GB 2017, 'The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study', Alzheimer's and Dementia, vol. 13, no. 9, pp. 1013-1023. https://doi.org/10.1016/j.jalz.2017.01.019

TY - JOUR

T1 - The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease

T2 - A European Alzheimer's Disease Consortium study

AU - Bosco, Paolo

AU - Redolfi, Alberto

AU - Bocchetta, Martina

AU - Ferrari, Clarissa

AU - Mega, Anna

AU - Galluzzi, Samantha

AU - Austin, Mark

AU - Chincarini, Andrea

AU - Collins, D. Louis

AU - Duchesne, Simon

AU - Maréchal, Bénédicte

AU - Roche, Alexis

AU - Sensi, Francesco

AU - Wolz, Robin

AU - Alegret, Montserrat

AU - Assal, Frederic

AU - Balasa, Mircea

AU - Bastin, Christine

AU - Bougea, Anastasia

AU - Emek-Savaş, Derya Durusu

AU - Engelborghs, Sebastiaan

AU - Grimmer, Timo

AU - Grosu, Galina

AU - Kramberger, Milica G.

AU - Lawlor, Brian

AU - Mandic Stojmenovic, Gorana

AU - Marinescu, Mihaela

AU - Mecocci, Patrizia

AU - Molinuevo, José Luis

AU - Morais, Ricardo

AU - Niemantsverdriet, Ellis

AU - Nobili, Flavio

AU - Ntovas, Konstantinos

AU - O'Dwyer, Sarah

AU - Paraskevas, George P.

AU - Pelini, Luca

AU - Picco, Agnese

AU - Salmon, Eric

AU - Santana, Isabel

AU - Sotolongo-Grau, Oscar

AU - Spiru, Luiza

AU - Stefanova, Elka

AU - Popovic, Katarina Surlan

AU - Tsolaki, Magda

AU - Yener, Görsev G.

AU - Zekry, Dina

AU - Frisoni, Giovanni B.

PY - 2017/9

Y1 - 2017/9

N2 - Introduction Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear. Methods Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini–Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed. Results An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of −8.0% (95% credible interval: [−11.5, −5.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, 18F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (−8.5, CrI: [−11.5, −5.6]; −14.1, CrI: [−19.3, −8.8]; −10.6, CrI: [−14.6, −6.1], respectively). Discussion There is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup.

AB - Introduction Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear. Methods Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini–Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed. Results An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of −8.0% (95% credible interval: [−11.5, −5.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, 18F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (−8.5, CrI: [−11.5, −5.6]; −14.1, CrI: [−19.3, −8.8]; −10.6, CrI: [−14.6, −6.1], respectively). Discussion There is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup.

KW - Alzheimer's disease

KW - Biomarkers

KW - Diagnostic confidence of AD

KW - Hippocampal volume

KW - Medial temporal lobe atrophy

UR - https://www.scopus.com/pages/publications/85014782159

U2 - 10.1016/j.jalz.2017.01.019

DO - 10.1016/j.jalz.2017.01.019

M3 - Article

C2 - 28263741

AN - SCOPUS:85014782159

SN - 1552-5260

VL - 13

SP - 1013

EP - 1023

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 9

ER -

The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this