@article{11763061af7d4160a73adec28240e7db,
title = "The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma",
abstract = "Heider et al. investigate the molecular function of immunomodulatory drugs (IMiDs) and describe their target, CRBN, as a transmembrane protein (TP)-specific co-chaperone of the HSP90-AHA1 axis. By disrupting CRBN-HSP90 interaction, IMiDs lead to destabilization of various TPs as CD98hc/LAT1, which serve as therapeutic targets in multiple myeloma.",
keywords = "CD98hc, CRBN, HSP90, IMiDs, LAT1, chaperones, multiple myeloma, protein quality control, radio-theranostics, ubiquitin",
author = "Michael Heider and Ruth Eichner and Jacob Stroh and Volker Morath and Anna Kuisl and Jana Zecha and Jannis Lawatscheck and Kheewoong Baek and Garz, \{Anne Kathrin\} and Martina Rudelius and Deuschle, \{Friedrich Christian\} and Ulrich Keller and Simone Lemeer and Mareike Verbeek and G{\"o}tze, \{Katharina S.\} and Arne Skerra and Weber, \{Wolfgang A.\} and Johannes Buchner and Schulman, \{Brenda A.\} and Bernhard Kuster and Vanesa Fern{\'a}ndez-S{\'a}iz and Florian Bassermann",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = mar,
day = "18",
doi = "10.1016/j.molcel.2020.12.046",
language = "English",
volume = "81",
pages = "1170--1186.e10",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "6",
}