TY - JOUR
T1 - The HuMet Repository
T2 - Watching human metabolism at work
AU - Weinisch, Patrick
AU - Raffler, Johannes
AU - Römisch-Margl, Werner
AU - Arnold, Matthias
AU - Mohney, Robert P.
AU - Rist, Manuela J.
AU - Prehn, Cornelia
AU - Skurk, Thomas
AU - Hauner, Hans
AU - Daniel, Hannelore
AU - Suhre, Karsten
AU - Kastenmüller, Gabi
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/8/27
Y1 - 2024/8/27
N2 - Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, exercise, and cold stress in healthy subjects. Metabolomics data from blood, urine, and breath of 15 young, healthy men at up to 56 time points are integrated and embedded within an interactive web application, enabling researchers with and without computational expertise to search, visualize, analyze, and contextualize the dynamic metabolite profiles of 2,656 metabolites acquired on multiple platforms. With examples, we demonstrate the utility of the resource for research into the dynamics of human metabolism, highlighting differences and similarities in systemic metabolic responses across challenges and the complementarity of metabolomics platforms. The repository, providing a reference for healthy metabolite changes to six standardized physiological challenges, is freely accessible through a web portal.
AB - Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, exercise, and cold stress in healthy subjects. Metabolomics data from blood, urine, and breath of 15 young, healthy men at up to 56 time points are integrated and embedded within an interactive web application, enabling researchers with and without computational expertise to search, visualize, analyze, and contextualize the dynamic metabolite profiles of 2,656 metabolites acquired on multiple platforms. With examples, we demonstrate the utility of the resource for research into the dynamics of human metabolism, highlighting differences and similarities in systemic metabolic responses across challenges and the complementarity of metabolomics platforms. The repository, providing a reference for healthy metabolite changes to six standardized physiological challenges, is freely accessible through a web portal.
KW - CP: Metabolism
KW - dynamic metabolic responses in health
KW - exercise metabolism
KW - metabolic flexibility
KW - metabolomics platform comparison
KW - oral glucose tolerance test
KW - oral lipid tolerance test
KW - postprandial metabolism
KW - prolonged/extended fasting
KW - standardized physiological challenge tests
KW - time-series metabolomics
UR - http://www.scopus.com/inward/record.url?scp=85199059032&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2024.114416
DO - 10.1016/j.celrep.2024.114416
M3 - Article
AN - SCOPUS:85199059032
SN - 2211-1247
VL - 43
JO - Cell Reports
JF - Cell Reports
IS - 8
M1 - 114416
ER -
