The human intestinal bacterium Eggerthella lenta influences gut metabolomes in gnotobiotic mice

Alina Viehof, Sven Bastiaan Haange, Theresa Streidl, Kristin Schubert, Beatrice Engelmann, Dirk Haller, Ulrike Rolle-Kampczyk, Martin von Bergen, Thomas Clavel

Research output: Contribution to journalArticlepeer-review


The intestinal microbiota and its metabolites are known to influence host metabolic health. However, little is known about the role of specific microbes. In this work, we used the minimal consortium Oligo-Mouse-Microbiota (OMM12) to study the function of Coriobacteriia under defined conditions in gnotobiotic mice. OMM12 mice with or without the addition of the dominant gut bacterium Eggerthella lenta (E. lenta) were fed with diets varying in fat content and primary bile acids. E. lenta stably colonised the mouse caecum at high relative abundances (median: 27.5%). This was accompanied by decreased occurrence of Akkermansia muciniphila and Enterococcus faecalis, but results did not reach statistical significance in all groups depending on diet and inter-individual differences. Changes in host parameters (anthropometry, blood glucose, and cholesterol) and liver proteomes were primarily due to diet. In contrast, metabolomes in colon content differed significantly between the colonisation groups. The presence of E. lenta was associated with elevated levels of latifolicinin C acid and decreased creatine, sarcosine, N,N-dimethylarginine, and N-Acetyl-DL-methionine. In conclusion, E. lenta altered specific metabolites in the colon but did not have significant effects on the mice or liver proteomes under the conditions tested due to marked inter-individual differences.

Original languageEnglish
Article number14
JournalMicrobiome Research Reports
Issue number2
StatePublished - Jun 2024


  • Eggerthella lenta
  • Gut microbiota
  • Oligo-Mouse-Microbiota
  • gut-liver axis
  • metabolomics
  • proteomics


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