The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

Franziska Greulich; Michael Wierer; Aikaterini Mechtidou; Omar Gonzalez-Garcia; N. Henriette Uhlenhaut

doi:10.1016/j.celrep.2021.108742

The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

Franziska Greulich, Michael Wierer, Aikaterini Mechtidou, Omar Gonzalez-Garcia, N. Henriette Uhlenhaut

Associate Professorship of Metabolic Programming

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Glucocorticoids such as dexamethasone are widely used immunomodulators. Combining proteomics, ChIP-seq, RNA-seq, and genetic loss-of-function studies in murine macrophages, Greulich et al. show that recruitment of the SETD1A/COMPASS complex to cis-regulatory elements by the glucocorticoid receptor mediates some of their anti-inflammatory actions.

Original language	English
Article number	108742
Journal	Cell Reports
Volume	34
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2021.108742
State	Published - 9 Feb 2021

Keywords

COMPASS complex
H3K4 methylation
SETD1A
dexamethasone
enhancers
genomics
glucocorticoid receptor
inflammation
macrophages
transcription

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10.1016/j.celrep.2021.108742

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title = "The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers",

abstract = "Glucocorticoids such as dexamethasone are widely used immunomodulators. Combining proteomics, ChIP-seq, RNA-seq, and genetic loss-of-function studies in murine macrophages, Greulich et al. show that recruitment of the SETD1A/COMPASS complex to cis-regulatory elements by the glucocorticoid receptor mediates some of their anti-inflammatory actions.",

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author = "Franziska Greulich and Michael Wierer and Aikaterini Mechtidou and Omar Gonzalez-Garcia and Uhlenhaut, {N. Henriette}",

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AU - Mechtidou, Aikaterini

AU - Gonzalez-Garcia, Omar

AU - Uhlenhaut, N. Henriette

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KW - H3K4 methylation

KW - SETD1A

KW - dexamethasone

KW - enhancers

KW - genomics

KW - glucocorticoid receptor

KW - inflammation

KW - macrophages

KW - transcription

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The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

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Keywords

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