The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis

J. Mark Wilkinson, Eleftheria Zeggini

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Congruent, low-friction relative movement between the articulating elements of a synovial joint is an essential pre-requisite for sustained, efficient, function. Where disorders of joint formation or maintenance exist, mechanical overloading and osteoarthritis (OA) follow. The heritable component of OA accounts for ~ 50% of susceptible risk. Although almost 100 genetic risk loci for OA have now been identified, and the epidemiological relationship between joint development, joint shape and osteoarthritis is well established, we still have only a limited understanding of the contribution that genetic variation makes to joint shape and how this modulates OA risk. In this article, a brief overview of synovial joint development and its genetic regulation is followed by a review of current knowledge on the genetic epidemiology of established joint shape disorders and common shape variation. A summary of current genetic epidemiology of OA is also given, together with current evidence on the genetic overlap between shape variation and OA. Finally, the established genetic risk loci for both joint shape and osteoarthritis are discussed.

Original languageEnglish
Pages (from-to)257-276
Number of pages20
JournalCalcified Tissue International
Volume109
Issue number3
DOIs
StatePublished - Sep 2021
Externally publishedYes

Keywords

  • Epidemiology
  • Genetics
  • Joint development
  • Joint shape
  • Osteoarthritis

Fingerprint

Dive into the research topics of 'The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis'. Together they form a unique fingerprint.

Cite this