TY - JOUR
T1 - The expression of histone deacetylase 1, but not other class i histone deacetylases, is significantly increased in endometriosis
AU - Samartzis, Eleftherios P.
AU - Noske, Aurelia
AU - Samartzis, Nicolas
AU - Fink, Daniel
AU - Imesch, Patrick
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This project was supported by a grant from the Center for Clinical Research, University and University Hospital Zurich and by grants from the EMDO and the Hartmann-Mueller foundations .
PY - 2013/12
Y1 - 2013/12
N2 - Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis samples and 30 normal endometrium controls. The mean HDAC-1 immunoreactivity score (IRS ± standard deviation) was 7.6 ± 2.5 in endometriosis and 5.3 ± 2.3 in normal endometrium (P <.001). In contrast, the IRSs of HDAC-2 and -3 were 11.7 ± 0.7 and 11.8 ± 1.1 in endometriosis and 11.6 ± 1.0 and 11.9 ± 0.4 in normal endometrium (P =.7 and P =.2), respectively. Significant correlations were found between HDAC-1 and estrogen (-alpha/-beta) and progesterone receptor expression. In conclusion, HDAC-1, but not HDAC-2/-3, was significantly increased in endometriosis and associated with steroid hormone receptor expression that may reflect interdependence. In context with the literature, specific inhibitors of HDAC-1 may have inhibitory activities similar to those of broad-spectrum HDAC inhibitors and may be clinically tolerated, which would increase their chance as an option in the treatment of endometriosis.
AB - Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis samples and 30 normal endometrium controls. The mean HDAC-1 immunoreactivity score (IRS ± standard deviation) was 7.6 ± 2.5 in endometriosis and 5.3 ± 2.3 in normal endometrium (P <.001). In contrast, the IRSs of HDAC-2 and -3 were 11.7 ± 0.7 and 11.8 ± 1.1 in endometriosis and 11.6 ± 1.0 and 11.9 ± 0.4 in normal endometrium (P =.7 and P =.2), respectively. Significant correlations were found between HDAC-1 and estrogen (-alpha/-beta) and progesterone receptor expression. In conclusion, HDAC-1, but not HDAC-2/-3, was significantly increased in endometriosis and associated with steroid hormone receptor expression that may reflect interdependence. In context with the literature, specific inhibitors of HDAC-1 may have inhibitory activities similar to those of broad-spectrum HDAC inhibitors and may be clinically tolerated, which would increase their chance as an option in the treatment of endometriosis.
KW - endometriosis
KW - estrogen and progesterone receptor
KW - histone deacetylases class I
UR - http://www.scopus.com/inward/record.url?scp=84887427995&partnerID=8YFLogxK
U2 - 10.1177/1933719113488450
DO - 10.1177/1933719113488450
M3 - Article
C2 - 23690335
AN - SCOPUS:84887427995
SN - 1933-7191
VL - 20
SP - 1416
EP - 1422
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 12
ER -