The expression of histone deacetylase 1, but not other class i histone deacetylases, is significantly increased in endometriosis

Eleftherios P. Samartzis, Aurelia Noske, Nicolas Samartzis, Daniel Fink, Patrick Imesch

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis samples and 30 normal endometrium controls. The mean HDAC-1 immunoreactivity score (IRS ± standard deviation) was 7.6 ± 2.5 in endometriosis and 5.3 ± 2.3 in normal endometrium (P <.001). In contrast, the IRSs of HDAC-2 and -3 were 11.7 ± 0.7 and 11.8 ± 1.1 in endometriosis and 11.6 ± 1.0 and 11.9 ± 0.4 in normal endometrium (P =.7 and P =.2), respectively. Significant correlations were found between HDAC-1 and estrogen (-alpha/-beta) and progesterone receptor expression. In conclusion, HDAC-1, but not HDAC-2/-3, was significantly increased in endometriosis and associated with steroid hormone receptor expression that may reflect interdependence. In context with the literature, specific inhibitors of HDAC-1 may have inhibitory activities similar to those of broad-spectrum HDAC inhibitors and may be clinically tolerated, which would increase their chance as an option in the treatment of endometriosis.

Original languageEnglish
Pages (from-to)1416-1422
Number of pages7
JournalReproductive Sciences
Volume20
Issue number12
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • endometriosis
  • estrogen and progesterone receptor
  • histone deacetylases class I

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