The emerging role of cell-free DNA as a molecular marker for cancer management

Abel Jacobus Bronkhorst, Vida Ungerer, Stefan Holdenrieder

Research output: Contribution to journalReview articlepeer-review

389 Scopus citations

Abstract

An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and monitoring. However, harnessing the full potential of cfDNA requires (i) the optimization and standardization of preanalytical steps, (ii) refinement of current analysis strategies, and, perhaps most importantly, (iii) significant improvements in our understanding of its origin, physical properties, and dynamics in circulation. The latter knowledge is crucial for interpreting the associations between changes in the baseline characteristics of cfDNA and the clinical manifestations of cancer. In this review we explore recent advancements and highlight the current gaps in our knowledge concerning each point of contact between cfDNA analysis and the different stages of cancer management.

Original languageEnglish
Article number100087
JournalBiomolecular Detection and Quantification
Volume17
DOIs
StatePublished - Mar 2019

Keywords

  • Biomarker
  • Cancer
  • Cell-free DNA
  • Circulating tumor DNA
  • Liquid biopsy
  • Precision oncology

Fingerprint

Dive into the research topics of 'The emerging role of cell-free DNA as a molecular marker for cancer management'. Together they form a unique fingerprint.

Cite this