The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

Adam P. Chambers; Henriette Kirchner; Hilary E. Wilson-Perez; Jill A. Willency; John E. Hale; Bruce D. Gaylinn; Michael O. Thorner; Paul T. Pfluger; Jesus A. Gutierrez; Matthias H. Tschöp; Darleen A. Sandoval; Randy J. Seeley

doi:10.1053/j.gastro.2012.09.009

The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

Adam P. Chambers, Henriette Kirchner, Hilary E. Wilson-Perez, Jill A. Willency, John E. Hale, Bruce D. Gaylinn, Michael O. Thorner, Paul T. Pfluger, Jesus A. Gutierrez, Matthias H. Tschöp, Darleen A. Sandoval, Randy J. Seeley

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.

Original language	English
Pages (from-to)	50-52.e5
Journal	Gastroenterology
Volume	144
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2012.09.009
State	Published - Jan 2013

Keywords

Bariatric Surgery
Obesity
Treatment
Weight-Loss Surgery

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10.1053/j.gastro.2012.09.009

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title = "The effects of vertical sleeve gastrectomy in rodents are ghrelin independent",

abstract = "Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.",

keywords = "Bariatric Surgery, Obesity, Treatment, Weight-Loss Surgery",

author = "Chambers, {Adam P.} and Henriette Kirchner and Wilson-Perez, {Hilary E.} and Willency, {Jill A.} and Hale, {John E.} and Gaylinn, {Bruce D.} and Thorner, {Michael O.} and Pfluger, {Paul T.} and Gutierrez, {Jesus A.} and Tsch{\"o}p, {Matthias H.} and Sandoval, {Darleen A.} and Seeley, {Randy J.}",

note = "Funding Information: Funding Supported by a grant from Ethicon Endo-Surgery, Inc , and a Canadian Institutes of Health Research fellowship (A.P.C.). ",

year = "2013",

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doi = "10.1053/j.gastro.2012.09.009",

language = "English",

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AU - Kirchner, Henriette

AU - Wilson-Perez, Hilary E.

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AU - Hale, John E.

AU - Gaylinn, Bruce D.

AU - Thorner, Michael O.

AU - Pfluger, Paul T.

AU - Gutierrez, Jesus A.

AU - Tschöp, Matthias H.

AU - Sandoval, Darleen A.

AU - Seeley, Randy J.

N1 - Funding Information: Funding Supported by a grant from Ethicon Endo-Surgery, Inc , and a Canadian Institutes of Health Research fellowship (A.P.C.).

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AB - Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.

KW - Bariatric Surgery

KW - Obesity

KW - Treatment

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The effects of vertical sleeve gastrectomy in rodents are ghrelin independent

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Keywords

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