The 'effects of transfusion thresholds on neurocognitive outcome of extremely low birth-weight infants (ETTNO)' study: Background, aims, and study protocol

Axel R. Franz; Rolf F. Maier; Ulrich H. Thome; Mario Rüdiger; Martina Kron; Dirk Bassler; Christian F. Poets; Ingeborg Krägeloh-Mann; Mark Schoberer; Sonja Trepels-Kottek; Gernot Buheitel; Wilfried Schenk; Christoph Bührer; Florian Guthmann; Lars Garten; Dieter Hüseman; Christoph Czernik; Rainer Rossi; Thomas Kühn; Elisabeth Eilers; Norbert Teig; Almut Weitkämper; Jes Reinholdt; Gitte Veiergang; Claudia Roll; Wolfgang Pielemeier; Violeta Ojinaga; Nicole Braun; Hans Jörg Bittrich; Kathrin Roefke; Michael Schroth; Hans Georg Topf; Anja Stein; Matthias Keller; Britta Maria Hüning; Doris Fischer; Horst Buxmann; Matthias Heckmann; Dirk Faas; Axel Von Der Wense; Peter Gudowius; Sarah Kabisch; Georg Hillebrand; Bettina Bohnhorst; Corinna Peter; Florian Urlichs; Marc Hoppenz; Thomas Pabst; Angela Kribs; Ruth Maria Klein; Christoph Hünseler; Bernhard Roth; Anne Vierzig; Frank Eifinger; André Oberthür; Kathrin Mehler; Corinna Gebauer; Matthias Knüpfer; Michael Zemlin; Larissa Mähnhardt; Claudia Franziska Nußbaum; Alexandra Schwepcke; Georg Rellensmann; Esther Rieger-Fackeldey; Jan Holger Schiffmann; Jens Grombach; Stefan Schäfer; Hugo Segerer; Annette Keller-Wackerbauer; Rainer Burghard; Mechthild Hubert; Matthias Vochem; Ulrich Pohlmann; Patrick Neuberger; Martin Wagner; Hans Fuchs; Manuel Schmid; Reinhard Hopfner; Hans Ulrich Bucher; Heike Rabe; Josef Högel; Corinna Engel; Joachim Riethmüller

doi:10.1159/000335030

The 'effects of transfusion thresholds on neurocognitive outcome of extremely low birth-weight infants (ETTNO)' study: Background, aims, and study protocol

Axel R. Franz, Rolf F. Maier, Ulrich H. Thome, Mario Rüdiger, Martina Kron, Dirk Bassler, Christian F. Poets, Ingeborg Krägeloh-Mann, Mark Schoberer, Sonja Trepels-Kottek, Gernot Buheitel, Wilfried Schenk, Christoph Bührer, Florian Guthmann, Lars Garten, Dieter Hüseman, Christoph Czernik, Rainer Rossi, Thomas Kühn, Elisabeth EilersNorbert Teig, Almut Weitkämper, Jes Reinholdt, Gitte Veiergang, Claudia Roll, Wolfgang Pielemeier, Violeta Ojinaga, Nicole Braun, Hans Jörg Bittrich, Kathrin Roefke, Michael Schroth, Hans Georg Topf, Anja Stein, Matthias Keller, Britta Maria Hüning, Doris Fischer, Horst Buxmann, Matthias Heckmann, Dirk Faas, Axel Von Der Wense, Peter Gudowius, Sarah Kabisch, Georg Hillebrand, Bettina Bohnhorst, Corinna Peter, Florian Urlichs, Marc Hoppenz, Thomas Pabst, Angela Kribs, Ruth Maria Klein, Christoph Hünseler, Bernhard Roth, Anne Vierzig, Frank Eifinger, André Oberthür, Kathrin Mehler, Corinna Gebauer, Matthias Knüpfer, Michael Zemlin, Larissa Mähnhardt, Claudia Franziska Nußbaum, Alexandra Schwepcke, Georg Rellensmann, Esther Rieger-Fackeldey, Jan Holger Schiffmann, Jens Grombach, Stefan Schäfer, Hugo Segerer, Annette Keller-Wackerbauer, Rainer Burghard, Mechthild Hubert, Matthias Vochem, Ulrich Pohlmann, Patrick Neuberger, Martin Wagner, Hans Fuchs, Manuel Schmid, Reinhard Hopfner, Hans Ulrich Bucher, Heike Rabe, Josef Högel, Corinna Engel, Joachim Riethmüller

Department of Pediatric Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Background: Infants with extremely low birth weight uniformly develop anemia of prematurity and frequently require red blood cell transfusions (RBCTs). Although RBCT is widely practiced, the indications remain controversial in the absence of conclusive data on the long-term effects of RBCT. Objectives: To summarize the current equipoise and to outline the study protocol of the 'Effects of Transfusion Thresholds on Neurocognitive Outcome of extremely low birth-weight infants (ETTNO)' study. Methods: Review of the literature and design of a large pragmatic randomized controlled trial of restrictive versus liberal RBCT guidelines enrolling 920 infants with birth weights of 400-999 g with long-term neurodevelopmental follow-up. Results and Conclusions: The results of ETTNO will provide definite data about the efficacy and safety of restrictive versus liberal RBCT guidelines in very preterm infants.

Original language	English
Pages (from-to)	301-305
Number of pages	5
Journal	Neonatology
Volume	101
Issue number	4
DOIs	https://doi.org/10.1159/000335030
State	Published - Jun 2012

Keywords

Anemia of prematurity, treatment
Infant, preterm
Randomized controlled trial
Transfusion

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10.1159/000335030

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Franz, A. R., Maier, R. F., Thome, U. H., Rüdiger, M., Kron, M., Bassler, D., Poets, C. F., Krägeloh-Mann, I., Schoberer, M., Trepels-Kottek, S., Buheitel, G., Schenk, W., Bührer, C., Guthmann, F., Garten, L., Hüseman, D., Czernik, C., Rossi, R., Kühn, T., ... Riethmüller, J. (2012). The 'effects of transfusion thresholds on neurocognitive outcome of extremely low birth-weight infants (ETTNO)' study: Background, aims, and study protocol. Neonatology, 101(4), 301-305. https://doi.org/10.1159/000335030

@article{342dd74d0e134b5e9fcdc1c8a94ae250,

title = "The 'effects of transfusion thresholds on neurocognitive outcome of extremely low birth-weight infants (ETTNO)' study: Background, aims, and study protocol",

abstract = "Background: Infants with extremely low birth weight uniformly develop anemia of prematurity and frequently require red blood cell transfusions (RBCTs). Although RBCT is widely practiced, the indications remain controversial in the absence of conclusive data on the long-term effects of RBCT. Objectives: To summarize the current equipoise and to outline the study protocol of the 'Effects of Transfusion Thresholds on Neurocognitive Outcome of extremely low birth-weight infants (ETTNO)' study. Methods: Review of the literature and design of a large pragmatic randomized controlled trial of restrictive versus liberal RBCT guidelines enrolling 920 infants with birth weights of 400-999 g with long-term neurodevelopmental follow-up. Results and Conclusions: The results of ETTNO will provide definite data about the efficacy and safety of restrictive versus liberal RBCT guidelines in very preterm infants.",

keywords = "Anemia of prematurity, treatment, Infant, preterm, Randomized controlled trial, Transfusion",

author = "Franz, {Axel R.} and Maier, {Rolf F.} and Thome, {Ulrich H.} and Mario R{\"u}diger and Martina Kron and Dirk Bassler and Poets, {Christian F.} and Ingeborg Kr{\"a}geloh-Mann and Mark Schoberer and Sonja Trepels-Kottek and Gernot Buheitel and Wilfried Schenk and Christoph B{\"u}hrer and Florian Guthmann and Lars Garten and Dieter H{\"u}seman and Christoph Czernik and Rainer Rossi and Thomas K{\"u}hn and Elisabeth Eilers and Norbert Teig and Almut Weitk{\"a}mper and Jes Reinholdt and Gitte Veiergang and Claudia Roll and Wolfgang Pielemeier and Violeta Ojinaga and Nicole Braun and Bittrich, {Hans J{\"o}rg} and Kathrin Roefke and Michael Schroth and Topf, {Hans Georg} and Anja Stein and Matthias Keller and H{\"u}ning, {Britta Maria} and Doris Fischer and Horst Buxmann and Matthias Heckmann and Dirk Faas and {Von Der Wense}, Axel and Peter Gudowius and Sarah Kabisch and Georg Hillebrand and Bettina Bohnhorst and Corinna Peter and Florian Urlichs and Marc Hoppenz and Thomas Pabst and Angela Kribs and Klein, {Ruth Maria} and Christoph H{\"u}nseler and Bernhard Roth and Anne Vierzig and Frank Eifinger and Andr{\'e} Oberth{\"u}r and Kathrin Mehler and Corinna Gebauer and Matthias Kn{\"u}pfer and Michael Zemlin and Larissa M{\"a}hnhardt and Nu{\ss}baum, {Claudia Franziska} and Alexandra Schwepcke and Georg Rellensmann and Esther Rieger-Fackeldey and Schiffmann, {Jan Holger} and Jens Grombach and Stefan Sch{\"a}fer and Hugo Segerer and Annette Keller-Wackerbauer and Rainer Burghard and Mechthild Hubert and Matthias Vochem and Ulrich Pohlmann and Patrick Neuberger and Martin Wagner and Hans Fuchs and Manuel Schmid and Reinhard Hopfner and Bucher, {Hans Ulrich} and Heike Rabe and Josef H{\"o}gel and Corinna Engel and Joachim Riethm{\"u}ller",

year = "2012",

month = jun,

doi = "10.1159/000335030",

language = "English",

volume = "101",

pages = "301--305",

journal = "Neonatology",

issn = "1661-7800",

publisher = "S. Karger AG",

number = "4",

}

Franz, AR, Maier, RF, Thome, UH, Rüdiger, M, Kron, M, Bassler, D, Poets, CF, Krägeloh-Mann, I, Schoberer, M, Trepels-Kottek, S, Buheitel, G, Schenk, W, Bührer, C, Guthmann, F, Garten, L, Hüseman, D, Czernik, C, Rossi, R, Kühn, T, Eilers, E, Teig, N, Weitkämper, A, Reinholdt, J, Veiergang, G, Roll, C, Pielemeier, W, Ojinaga, V, Braun, N, Bittrich, HJ, Roefke, K, Schroth, M, Topf, HG, Stein, A, Keller, M, Hüning, BM, Fischer, D, Buxmann, H, Heckmann, M, Faas, D, Von Der Wense, A, Gudowius, P, Kabisch, S, Hillebrand, G, Bohnhorst, B, Peter, C, Urlichs, F, Hoppenz, M, Pabst, T, Kribs, A, Klein, RM, Hünseler, C, Roth, B, Vierzig, A, Eifinger, F, Oberthür, A, Mehler, K, Gebauer, C, Knüpfer, M, Zemlin, M, Mähnhardt, L, Nußbaum, CF, Schwepcke, A, Rellensmann, G, Rieger-Fackeldey, E, Schiffmann, JH, Grombach, J, Schäfer, S, Segerer, H, Keller-Wackerbauer, A, Burghard, R, Hubert, M, Vochem, M, Pohlmann, U, Neuberger, P, Wagner, M, Fuchs, H, Schmid, M, Hopfner, R, Bucher, HU, Rabe, H, Högel, J, Engel, C & Riethmüller, J 2012, 'The 'effects of transfusion thresholds on neurocognitive outcome of extremely low birth-weight infants (ETTNO)' study: Background, aims, and study protocol', Neonatology, vol. 101, no. 4, pp. 301-305. https://doi.org/10.1159/000335030

TY - JOUR

T1 - The 'effects of transfusion thresholds on neurocognitive outcome of extremely low birth-weight infants (ETTNO)' study

T2 - Background, aims, and study protocol

AU - Franz, Axel R.

AU - Maier, Rolf F.

AU - Thome, Ulrich H.

AU - Rüdiger, Mario

AU - Kron, Martina

AU - Bassler, Dirk

AU - Poets, Christian F.

AU - Krägeloh-Mann, Ingeborg

AU - Schoberer, Mark

AU - Trepels-Kottek, Sonja

AU - Buheitel, Gernot

AU - Schenk, Wilfried

AU - Bührer, Christoph

AU - Guthmann, Florian

AU - Garten, Lars

AU - Hüseman, Dieter

AU - Czernik, Christoph

AU - Rossi, Rainer

AU - Kühn, Thomas

AU - Eilers, Elisabeth

AU - Teig, Norbert

AU - Weitkämper, Almut

AU - Reinholdt, Jes

AU - Veiergang, Gitte

AU - Roll, Claudia

AU - Pielemeier, Wolfgang

AU - Ojinaga, Violeta

AU - Braun, Nicole

AU - Bittrich, Hans Jörg

AU - Roefke, Kathrin

AU - Schroth, Michael

AU - Topf, Hans Georg

AU - Stein, Anja

AU - Keller, Matthias

AU - Hüning, Britta Maria

AU - Fischer, Doris

AU - Buxmann, Horst

AU - Heckmann, Matthias

AU - Faas, Dirk

AU - Von Der Wense, Axel

AU - Gudowius, Peter

AU - Kabisch, Sarah

AU - Hillebrand, Georg

AU - Bohnhorst, Bettina

AU - Peter, Corinna

AU - Urlichs, Florian

AU - Hoppenz, Marc

AU - Pabst, Thomas

AU - Kribs, Angela

AU - Klein, Ruth Maria

AU - Hünseler, Christoph

AU - Roth, Bernhard

AU - Vierzig, Anne

AU - Eifinger, Frank

AU - Oberthür, André

AU - Mehler, Kathrin

AU - Gebauer, Corinna

AU - Knüpfer, Matthias

AU - Zemlin, Michael

AU - Mähnhardt, Larissa

AU - Nußbaum, Claudia Franziska

AU - Schwepcke, Alexandra

AU - Rellensmann, Georg

AU - Rieger-Fackeldey, Esther

AU - Schiffmann, Jan Holger

AU - Grombach, Jens

AU - Schäfer, Stefan

AU - Segerer, Hugo

AU - Keller-Wackerbauer, Annette

AU - Burghard, Rainer

AU - Hubert, Mechthild

AU - Vochem, Matthias

AU - Pohlmann, Ulrich

AU - Neuberger, Patrick

AU - Wagner, Martin

AU - Fuchs, Hans

AU - Schmid, Manuel

AU - Hopfner, Reinhard

AU - Bucher, Hans Ulrich

AU - Rabe, Heike

AU - Högel, Josef

AU - Engel, Corinna

AU - Riethmüller, Joachim

PY - 2012/6

Y1 - 2012/6

N2 - Background: Infants with extremely low birth weight uniformly develop anemia of prematurity and frequently require red blood cell transfusions (RBCTs). Although RBCT is widely practiced, the indications remain controversial in the absence of conclusive data on the long-term effects of RBCT. Objectives: To summarize the current equipoise and to outline the study protocol of the 'Effects of Transfusion Thresholds on Neurocognitive Outcome of extremely low birth-weight infants (ETTNO)' study. Methods: Review of the literature and design of a large pragmatic randomized controlled trial of restrictive versus liberal RBCT guidelines enrolling 920 infants with birth weights of 400-999 g with long-term neurodevelopmental follow-up. Results and Conclusions: The results of ETTNO will provide definite data about the efficacy and safety of restrictive versus liberal RBCT guidelines in very preterm infants.

AB - Background: Infants with extremely low birth weight uniformly develop anemia of prematurity and frequently require red blood cell transfusions (RBCTs). Although RBCT is widely practiced, the indications remain controversial in the absence of conclusive data on the long-term effects of RBCT. Objectives: To summarize the current equipoise and to outline the study protocol of the 'Effects of Transfusion Thresholds on Neurocognitive Outcome of extremely low birth-weight infants (ETTNO)' study. Methods: Review of the literature and design of a large pragmatic randomized controlled trial of restrictive versus liberal RBCT guidelines enrolling 920 infants with birth weights of 400-999 g with long-term neurodevelopmental follow-up. Results and Conclusions: The results of ETTNO will provide definite data about the efficacy and safety of restrictive versus liberal RBCT guidelines in very preterm infants.

KW - Anemia of prematurity, treatment

KW - Infant, preterm

KW - Randomized controlled trial

KW - Transfusion

UR - http://www.scopus.com/inward/record.url?scp=84862200768&partnerID=8YFLogxK

U2 - 10.1159/000335030

DO - 10.1159/000335030

M3 - Article

AN - SCOPUS:84862200768

SN - 1661-7800

VL - 101

SP - 301

EP - 305

JO - Neonatology

JF - Neonatology

IS - 4

ER -

The 'effects of transfusion thresholds on neurocognitive outcome of extremely low birth-weight infants (ETTNO)' study: Background, aims, and study protocol

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Keywords

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