The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy

Rob S.B. Beanlands; William F. Armstrong; Rodney J. Hicks; John Nicklas; Charles Moore; Gary D. Hutchins; H. Georg Wolpers; Markus Schwaiger

doi:10.1007/BF02940007

The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy

Rob S.B. Beanlands, William F. Armstrong, Rodney J. Hicks, John Nicklas, Charles Moore, Gary D. Hutchins, H. Georg Wolpers, Markus Schwaiger

University of Michigan Medical School

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Methods and Results: With echocardiography and dynamic carbon 11-labeled acetate (C-11 acetate) positron emission tomographic imaging, C-11 acetate kinetics and a parameter that estimates mechanical ventricular efficiency (the work metabolic index) were defined in eight patients with dilated cardiomyopathy. The effect of afterload reduction with nitroprusside on these parameters was evaluated in six of these patients. Nitroprusside increased stroke work index but decreased the C-11 clearance rate. The work metabolic index determined noninvasively increased and correlated well with an invasive approach. The work metabolic index was inversely correlated with systemic vascular resistance. Nitroprusside shifted this relationship upward and to the left. Conclusion: This method of estimating efficiency is feasible and may represent a unique noninvasive approach for the evaluation of cardiac performance and responses to therapy.

Original language	English
Pages (from-to)	3-16
Number of pages	14
Journal	Journal of Nuclear Cardiology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1007/BF02940007
State	Published - Jan 1994
Externally published	Yes

Keywords

echocardiography
heart failure
mechanical efficiency
oxidative metabolism
positron emission tomography
stroke work
systemic vascular resistance

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10.1007/BF02940007

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Beanlands, R. S. B., Armstrong, W. F., Hicks, R. J., Nicklas, J., Moore, C., Hutchins, G. D., Wolpers, H. G., & Schwaiger, M. (1994). The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy. Journal of Nuclear Cardiology, 1(1), 3-16. https://doi.org/10.1007/BF02940007

@article{8a904512d85f4bf494fa854ec91520c7,

title = "The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy",

abstract = "Methods and Results: With echocardiography and dynamic carbon 11-labeled acetate (C-11 acetate) positron emission tomographic imaging, C-11 acetate kinetics and a parameter that estimates mechanical ventricular efficiency (the work metabolic index) were defined in eight patients with dilated cardiomyopathy. The effect of afterload reduction with nitroprusside on these parameters was evaluated in six of these patients. Nitroprusside increased stroke work index but decreased the C-11 clearance rate. The work metabolic index determined noninvasively increased and correlated well with an invasive approach. The work metabolic index was inversely correlated with systemic vascular resistance. Nitroprusside shifted this relationship upward and to the left. Conclusion: This method of estimating efficiency is feasible and may represent a unique noninvasive approach for the evaluation of cardiac performance and responses to therapy.",

keywords = "echocardiography, heart failure, mechanical efficiency, oxidative metabolism, positron emission tomography, stroke work, systemic vascular resistance",

author = "Beanlands, {Rob S.B.} and Armstrong, {William F.} and Hicks, {Rodney J.} and John Nicklas and Charles Moore and Hutchins, {Gary D.} and Wolpers, {H. Georg} and Markus Schwaiger",

year = "1994",

month = jan,

doi = "10.1007/BF02940007",

language = "English",

volume = "1",

pages = "3--16",

journal = "Journal of Nuclear Cardiology",

issn = "1071-3581",

publisher = "American Society of Nuclear Cardiology",

number = "1",

}

Beanlands, RSB, Armstrong, WF, Hicks, RJ, Nicklas, J, Moore, C, Hutchins, GD, Wolpers, HG & Schwaiger, M 1994, 'The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy', Journal of Nuclear Cardiology, vol. 1, no. 1, pp. 3-16. https://doi.org/10.1007/BF02940007

The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy. / Beanlands, Rob S.B.; Armstrong, William F.; Hicks, Rodney J. et al.
In: Journal of Nuclear Cardiology, Vol. 1, No. 1, 01.1994, p. 3-16.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy

AU - Beanlands, Rob S.B.

AU - Armstrong, William F.

AU - Hicks, Rodney J.

AU - Nicklas, John

AU - Moore, Charles

AU - Hutchins, Gary D.

AU - Wolpers, H. Georg

AU - Schwaiger, Markus

PY - 1994/1

Y1 - 1994/1

N2 - Methods and Results: With echocardiography and dynamic carbon 11-labeled acetate (C-11 acetate) positron emission tomographic imaging, C-11 acetate kinetics and a parameter that estimates mechanical ventricular efficiency (the work metabolic index) were defined in eight patients with dilated cardiomyopathy. The effect of afterload reduction with nitroprusside on these parameters was evaluated in six of these patients. Nitroprusside increased stroke work index but decreased the C-11 clearance rate. The work metabolic index determined noninvasively increased and correlated well with an invasive approach. The work metabolic index was inversely correlated with systemic vascular resistance. Nitroprusside shifted this relationship upward and to the left. Conclusion: This method of estimating efficiency is feasible and may represent a unique noninvasive approach for the evaluation of cardiac performance and responses to therapy.

AB - Methods and Results: With echocardiography and dynamic carbon 11-labeled acetate (C-11 acetate) positron emission tomographic imaging, C-11 acetate kinetics and a parameter that estimates mechanical ventricular efficiency (the work metabolic index) were defined in eight patients with dilated cardiomyopathy. The effect of afterload reduction with nitroprusside on these parameters was evaluated in six of these patients. Nitroprusside increased stroke work index but decreased the C-11 clearance rate. The work metabolic index determined noninvasively increased and correlated well with an invasive approach. The work metabolic index was inversely correlated with systemic vascular resistance. Nitroprusside shifted this relationship upward and to the left. Conclusion: This method of estimating efficiency is feasible and may represent a unique noninvasive approach for the evaluation of cardiac performance and responses to therapy.

KW - echocardiography

KW - heart failure

KW - mechanical efficiency

KW - oxidative metabolism

KW - positron emission tomography

KW - stroke work

KW - systemic vascular resistance

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The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy

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