The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na+‐K+‐ATPase after Partial Delipidisation with Lubrol®

S. Magour; H. Mäser; H. Greim

doi:10.1111/j.1600-0773.1987.tb01730.x

The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na⁺‐K⁺‐ATPase after Partial Delipidisation with Lubrol®

S. Magour
, H. Mäser
, H. Greim

Helmholtz Zentrum München German Research Center for Environmental Health

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Abstract: The microsomal Na⁺‐K⁺‐ATPase of rat brain was inhibited by mercury chloride and methyl mercury. The IC₅₀ was 6.5 × 10^‐7 M for mercury chloride and 3.5 × 10^‐6 M for methyl mercury. The inhibition was of a non‐competetive type with respect to ATP. The non‐ionic detergent Lubrol^$rG potentiated the inhibitory effect of both mercurials. It is concluded that Lubrol^$rG removes the bulk lipids present outside the catalytic center of the enzyme. Consequently, the enzyme will become more sensitive to the inhibition by both mercurials. 1987 Nordic Pharmacological Society

Original language	English
Pages (from-to)	184-186
Number of pages	3
Journal	Pharmacology & Toxicology
Volume	60
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0773.1987.tb01730.x
State	Published - Mar 1987
Externally published	Yes

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10.1111/j.1600-0773.1987.tb01730.x

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title = "The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na+‐K+‐ATPase after Partial Delipidisation with Lubrol{\textregistered}",

abstract = "Abstract: The microsomal Na+‐K+‐ATPase of rat brain was inhibited by mercury chloride and methyl mercury. The IC50 was 6.5 × 10‐7 M for mercury chloride and 3.5 × 10‐6 M for methyl mercury. The inhibition was of a non‐competetive type with respect to ATP. The non‐ionic detergent Lubrol\$rG potentiated the inhibitory effect of both mercurials. It is concluded that Lubrol\$rG removes the bulk lipids present outside the catalytic center of the enzyme. Consequently, the enzyme will become more sensitive to the inhibition by both mercurials. 1987 Nordic Pharmacological Society",

author = "S. Magour and H. M{\"a}ser and H. Greim",

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doi = "10.1111/j.1600-0773.1987.tb01730.x",

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AU - Magour, S.

AU - Mäser, H.

AU - Greim, H.

PY - 1987/3

Y1 - 1987/3

N2 - Abstract: The microsomal Na+‐K+‐ATPase of rat brain was inhibited by mercury chloride and methyl mercury. The IC50 was 6.5 × 10‐7 M for mercury chloride and 3.5 × 10‐6 M for methyl mercury. The inhibition was of a non‐competetive type with respect to ATP. The non‐ionic detergent Lubrol$rG potentiated the inhibitory effect of both mercurials. It is concluded that Lubrol$rG removes the bulk lipids present outside the catalytic center of the enzyme. Consequently, the enzyme will become more sensitive to the inhibition by both mercurials. 1987 Nordic Pharmacological Society

AB - Abstract: The microsomal Na+‐K+‐ATPase of rat brain was inhibited by mercury chloride and methyl mercury. The IC50 was 6.5 × 10‐7 M for mercury chloride and 3.5 × 10‐6 M for methyl mercury. The inhibition was of a non‐competetive type with respect to ATP. The non‐ionic detergent Lubrol$rG potentiated the inhibitory effect of both mercurials. It is concluded that Lubrol$rG removes the bulk lipids present outside the catalytic center of the enzyme. Consequently, the enzyme will become more sensitive to the inhibition by both mercurials. 1987 Nordic Pharmacological Society

UR - https://www.scopus.com/pages/publications/0023091034

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JF - Pharmacology & Toxicology

IS - 3

ER -

The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na⁺‐K⁺‐ATPase after Partial Delipidisation with Lubrol®

Abstract

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