The Effect of Mercury Chloride and Methyl Mercury on Brain Microsomal Na+‐K+‐ATPase after Partial Delipidisation with Lubrol®

S. Magour, H. Mäser, H. Greim

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28 Scopus citations

Abstract

Abstract: The microsomal Na+‐K+‐ATPase of rat brain was inhibited by mercury chloride and methyl mercury. The IC50 was 6.5 × 10‐7 M for mercury chloride and 3.5 × 10‐6 M for methyl mercury. The inhibition was of a non‐competetive type with respect to ATP. The non‐ionic detergent Lubrol$rG potentiated the inhibitory effect of both mercurials. It is concluded that Lubrol$rG removes the bulk lipids present outside the catalytic center of the enzyme. Consequently, the enzyme will become more sensitive to the inhibition by both mercurials. 1987 Nordic Pharmacological Society

Original languageEnglish
Pages (from-to)184-186
Number of pages3
JournalPharmacology & Toxicology
Volume60
Issue number3
DOIs
StatePublished - Mar 1987
Externally publishedYes

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