The effect of insulin-like growth factor-I, relaxin and luteinizing hormone on vascular endothelial growth factor secretion by cultured endometrial stromal cells on different days of early pregnancy in pigs

  • Monika M. Kaczmarek
  • , Agnieszka Blitek
  • , Dieter Schams
  • , Adam J. Ziecik

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The effect of insulin-like growth factor-I (IGF-I), relaxin (RLX) and luteinizing hormone (LH) on vascular endothelial growth factor (VEGF) in vitro secretion by endometrial stromal cells in pigs was investigated on days 10-12 and 20-22 of gestation. LH-stimulated stromal cell secretion of VEGF did not differ among tested days of early pregnancy. However, IGF-I- and RLX-mediated release of VEGF depended on the day of pregnancy. It seems that IGF-I and RLX may be considered as potent activators of VEGF-mediated angiogenesis in porcine endometrium, and their action may be more pronounced during maternal recognition of pregnancy.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalReproductive biology
Volume8
Issue number2
DOIs
StatePublished - Jul 2008

Keywords

  • Angiogenesis
  • Early pregnancy
  • Endometrium
  • VEGF secretion

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