The effect of insulin-like growth factor-I, relaxin and luteinizing hormone on vascular endothelial growth factor secretion by cultured endometrial stromal cells on different days of early pregnancy in pigs

Monika M. Kaczmarek, Agnieszka Blitek, Dieter Schams, Adam J. Ziecik

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The effect of insulin-like growth factor-I (IGF-I), relaxin (RLX) and luteinizing hormone (LH) on vascular endothelial growth factor (VEGF) in vitro secretion by endometrial stromal cells in pigs was investigated on days 10-12 and 20-22 of gestation. LH-stimulated stromal cell secretion of VEGF did not differ among tested days of early pregnancy. However, IGF-I- and RLX-mediated release of VEGF depended on the day of pregnancy. It seems that IGF-I and RLX may be considered as potent activators of VEGF-mediated angiogenesis in porcine endometrium, and their action may be more pronounced during maternal recognition of pregnancy.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalReproductive biology
Volume8
Issue number2
DOIs
StatePublished - Jul 2008

Keywords

  • Angiogenesis
  • Early pregnancy
  • Endometrium
  • VEGF secretion

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