The effect of fetal irradiation on the growth of postnatally xenotransplanted tumour cells

J. Plendl, W. Schmahl, U. Heinzmann

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Exposure of the mouse fetus (NMRI-strain) to 1·0 Gy X-irradiation has a marked effect on postnatally xenotransplanted glioma cells. In comparison to non-irradiated animals, irradiation on gestation day 14 resulted in: (a) a significantly higher rate of animals which failed to develop visible tumours growing from the inoculum; (b) a significant inhibition of the growth rate of solid gliomas; (c) a pronounced granulocytic and mast cell infiltration, and tissue necrosis, in the invading gliomas. The results suggest that irradiation in prenatal life exerts an amplifying effect on the antitumour response in postnatal life.

Original languageEnglish
Pages (from-to)821-827
Number of pages7
JournalInternational Journal of Radiation Biology
Volume55
Issue number5
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Dive into the research topics of 'The effect of fetal irradiation on the growth of postnatally xenotransplanted tumour cells'. Together they form a unique fingerprint.

Cite this