The diallelic locus encoding the minor histocompatibility antigen HA-1 is evolutionarily conserved

B. Wieles, J. Pool, M. Wilke, M. Weber, H. J. Kolb, R. E. Bontrop, E. Goulmy

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The polymorphic minor histocompatibility antigen HA-1 induces powerful T-cell alloreactivities with important consequences for graft-vs-tumor activity and development of graft-vs-host disease in patients after human leukocyte antigen-matched stem-cell transplantation (SCT). In view of possible translational animal studies, we analyzed the evolutionary conservation of the diallelic HA-1 locus in four mammalian species. Our results show that rodents do not encode the HA-1H allele, neither show polymorphism in this position on the HA-1 gene. Contrariwise, the HA-1H allele is present in non-human primate species and dogs. Interestingly, both the HA-1H T-cell epitope and its non-immunogenic counterpart HA-1R are present in the latter species. Thus, the HA-1 allelic polymorphism is conserved in evolution in primates and dogs.

Original languageEnglish
Pages (from-to)62-65
Number of pages4
JournalTissue Antigens
Volume68
Issue number1
DOIs
StatePublished - Jul 2006
Externally publishedYes

Keywords

  • Evolution
  • Minor histocompatibility antigen HA-1
  • Single nucleotide polymorphism
  • T cell epitope

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