Abstract
The polymorphic minor histocompatibility antigen HA-1 induces powerful T-cell alloreactivities with important consequences for graft-vs-tumor activity and development of graft-vs-host disease in patients after human leukocyte antigen-matched stem-cell transplantation (SCT). In view of possible translational animal studies, we analyzed the evolutionary conservation of the diallelic HA-1 locus in four mammalian species. Our results show that rodents do not encode the HA-1H allele, neither show polymorphism in this position on the HA-1 gene. Contrariwise, the HA-1H allele is present in non-human primate species and dogs. Interestingly, both the HA-1H T-cell epitope and its non-immunogenic counterpart HA-1R are present in the latter species. Thus, the HA-1 allelic polymorphism is conserved in evolution in primates and dogs.
Original language | English |
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Pages (from-to) | 62-65 |
Number of pages | 4 |
Journal | Tissue Antigens |
Volume | 68 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2006 |
Externally published | Yes |
Keywords
- Evolution
- Minor histocompatibility antigen HA-1
- Single nucleotide polymorphism
- T cell epitope