The diagnostic value of adiponectin multimers in healthy men undergoing screening for prostate cancer

Edward A. Medina; Xiaoyu Shi; Marcia H. Grayson; Donna P. Ankerst; Carolina B. Livi; Maria V. Medina; Ian M. Thompson; Robin J. Leach

doi:10.1158/1055-9965.EPI-13-0574

The diagnostic value of adiponectin multimers in healthy men undergoing screening for prostate cancer

Edward A. Medina
, Xiaoyu Shi
, Marcia H. Grayson
, Donna P. Ankerst
, Carolina B. Livi
, Maria V. Medina
, Ian M. Thompson
, Robin J. Leach

Associate Professorship of Biostatistics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Adiponectin has been reported to have a prohibitory effect on prostate cancer. The goal of this study was to evaluate the diagnostic value of adiponectin multimers for prostate cancer. Methods: Total adiponectin, high- and low-molecular-weight (HMW, LMW), ratios of these measures, and body mass index (BMI) were compared in a prospective prostate cancer-screened cohort. Multivariable logistic regression was used to assess the association between adiponectin measures, their interaction with BMI, and risk of prostate cancer and Gleason score upgrading from biopsy to prostatectomy. Results: A total of 228 prostate cancer cases and 239 controls were analyzed: 72 (31.6%) of the cancer cases were high grade (Gleason grade

Original language	English
Pages (from-to)	309-315
Number of pages	7
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	23
Issue number	2
DOIs	https://doi.org/10.1158/1055-9965.EPI-13-0574
State	Published - Feb 2014

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10.1158/1055-9965.EPI-13-0574

Cite this

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title = "The diagnostic value of adiponectin multimers in healthy men undergoing screening for prostate cancer",

abstract = "Background: Adiponectin has been reported to have a prohibitory effect on prostate cancer. The goal of this study was to evaluate the diagnostic value of adiponectin multimers for prostate cancer. Methods: Total adiponectin, high- and low-molecular-weight (HMW, LMW), ratios of these measures, and body mass index (BMI) were compared in a prospective prostate cancer-screened cohort. Multivariable logistic regression was used to assess the association between adiponectin measures, their interaction with BMI, and risk of prostate cancer and Gleason score upgrading from biopsy to prostatectomy. Results: A total of 228 prostate cancer cases and 239 controls were analyzed: 72 (31.6\%) of the cancer cases were high grade (Gleason grade",

author = "Medina, \{Edward A.\} and Xiaoyu Shi and Grayson, \{Marcia H.\} and Ankerst, \{Donna P.\} and Livi, \{Carolina B.\} and Medina, \{Maria V.\} and Thompson, \{Ian M.\} and Leach, \{Robin J.\}",

year = "2014",

month = feb,

doi = "10.1158/1055-9965.EPI-13-0574",

language = "English",

volume = "23",

pages = "309--315",

journal = "Cancer Epidemiology Biomarkers and Prevention",

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T1 - The diagnostic value of adiponectin multimers in healthy men undergoing screening for prostate cancer

AU - Medina, Edward A.

AU - Shi, Xiaoyu

AU - Grayson, Marcia H.

AU - Ankerst, Donna P.

AU - Livi, Carolina B.

AU - Medina, Maria V.

AU - Thompson, Ian M.

AU - Leach, Robin J.

PY - 2014/2

Y1 - 2014/2

N2 - Background: Adiponectin has been reported to have a prohibitory effect on prostate cancer. The goal of this study was to evaluate the diagnostic value of adiponectin multimers for prostate cancer. Methods: Total adiponectin, high- and low-molecular-weight (HMW, LMW), ratios of these measures, and body mass index (BMI) were compared in a prospective prostate cancer-screened cohort. Multivariable logistic regression was used to assess the association between adiponectin measures, their interaction with BMI, and risk of prostate cancer and Gleason score upgrading from biopsy to prostatectomy. Results: A total of 228 prostate cancer cases and 239 controls were analyzed: 72 (31.6%) of the cancer cases were high grade (Gleason grade

AB - Background: Adiponectin has been reported to have a prohibitory effect on prostate cancer. The goal of this study was to evaluate the diagnostic value of adiponectin multimers for prostate cancer. Methods: Total adiponectin, high- and low-molecular-weight (HMW, LMW), ratios of these measures, and body mass index (BMI) were compared in a prospective prostate cancer-screened cohort. Multivariable logistic regression was used to assess the association between adiponectin measures, their interaction with BMI, and risk of prostate cancer and Gleason score upgrading from biopsy to prostatectomy. Results: A total of 228 prostate cancer cases and 239 controls were analyzed: 72 (31.6%) of the cancer cases were high grade (Gleason grade

UR - https://www.scopus.com/pages/publications/84893677638

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DO - 10.1158/1055-9965.EPI-13-0574

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AN - SCOPUS:84893677638

SN - 1055-9965

VL - 23

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JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 2

ER -

The diagnostic value of adiponectin multimers in healthy men undergoing screening for prostate cancer

Abstract

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