The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul; Yenni A. Garcia; Bettina Zierer; Chaitanya Patwardhan; Omar Gutierrez; Zacariah Hildenbrand; Diondra C. Harris; Heather A. Balsiger; Jeffrey C. Sivils; Jill L. Johnson; Johannes Buchner; Ahmed Chadli; Marc B. Cox

doi:10.1074/jbc.M113.535229

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul
, Yenni A. Garcia
, Bettina Zierer
, Chaitanya Patwardhan
, Omar Gutierrez
, Zacariah Hildenbrand
, Diondra C. Harris
, Heather A. Balsiger
, Jeffrey C. Sivils
, Jill L. Johnson
, Johannes Buchner
, Ahmed Chadli
, Marc B. Cox

University of Texas
Center for Integrated Protein Science
Medical College of Georgia
University of Idaho

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

Original language	English
Pages (from-to)	15297-15308
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M113.535229
State	Published - 30 May 2014
Externally published	Yes

Access to Document

10.1074/jbc.M113.535229

Cite this

Paul, A., Garcia, Y. A., Zierer, B., Patwardhan, C., Gutierrez, O., Hildenbrand, Z., Harris, D. C., Balsiger, H. A., Sivils, J. C., Johnson, J. L., Buchner, J., Chadli, A., & Cox, M. B. (2014). The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. Journal of Biological Chemistry, 289(22), 15297-15308. https://doi.org/10.1074/jbc.M113.535229

@article{41f222042b43442986eed1d107fb6eef,

title = "The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors",

abstract = "Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.",

author = "Atanu Paul and Garcia, \{Yenni A.\} and Bettina Zierer and Chaitanya Patwardhan and Omar Gutierrez and Zacariah Hildenbrand and Harris, \{Diondra C.\} and Balsiger, \{Heather A.\} and Sivils, \{Jeffrey C.\} and Johnson, \{Jill L.\} and Johannes Buchner and Ahmed Chadli and Cox, \{Marc B.\}",

year = "2014",

month = may,

day = "30",

doi = "10.1074/jbc.M113.535229",

language = "English",

volume = "289",

pages = "15297--15308",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "22",

}

Paul, A, Garcia, YA, Zierer, B, Patwardhan, C, Gutierrez, O, Hildenbrand, Z, Harris, DC, Balsiger, HA, Sivils, JC, Johnson, JL, Buchner, J, Chadli, A & Cox, MB 2014, 'The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors', Journal of Biological Chemistry, vol. 289, no. 22, pp. 15297-15308. https://doi.org/10.1074/jbc.M113.535229

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. / Paul, Atanu; Garcia, Yenni A.; Zierer, Bettina et al.
In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15297-15308.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

AU - Paul, Atanu

AU - Garcia, Yenni A.

AU - Zierer, Bettina

AU - Patwardhan, Chaitanya

AU - Gutierrez, Omar

AU - Hildenbrand, Zacariah

AU - Harris, Diondra C.

AU - Balsiger, Heather A.

AU - Sivils, Jeffrey C.

AU - Johnson, Jill L.

AU - Buchner, Johannes

AU - Chadli, Ahmed

AU - Cox, Marc B.

PY - 2014/5/30

Y1 - 2014/5/30

N2 - Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

AB - Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

UR - https://www.scopus.com/pages/publications/84901720583

U2 - 10.1074/jbc.M113.535229

DO - 10.1074/jbc.M113.535229

M3 - Article

C2 - 24753260

AN - SCOPUS:84901720583

SN - 0021-9258

VL - 289

SP - 15297

EP - 15308

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 22

ER -

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Abstract

Access to Document

Other files and links

Fingerprint

Cite this