The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics

Oxana Pester; Alexander Götz; Gerd Multhaup; Christina Scharnagl; Dieter Langosch

doi:10.1002/cbic.201300322

The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics

Oxana Pester
, Alexander Götz
, Gerd Multhaup
, Christina Scharnagl
, Dieter Langosch

Chair of Biopolymer Chemistry

Technical University of Munich
Roche Innovation Center Munich
McGill University and Génome Québec Innovation Centre

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Wobbly backbone: The backbone dynamics of the amyloid precursor protein (APP) transmembrane helix was compared to those of other transmembrane domains. In contrast to expectation, no above-average backbone dynamics was found for the APP transmembrane helix; the dynamics thus appears not to be optimized for cleavage.

Original language	English
Pages (from-to)	1943-1948
Number of pages	6
Journal	ChemBioChem
Volume	14
Issue number	15
DOIs	https://doi.org/10.1002/cbic.201300322
State	Published - Oct 2013

Keywords

Alzheimer's disease
Amide exchange
Amyloid precursor proteins
Membrane proteins
Molecular dynamics
Transmembrane domains

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10.1002/cbic.201300322

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abstract = "Wobbly backbone: The backbone dynamics of the amyloid precursor protein (APP) transmembrane helix was compared to those of other transmembrane domains. In contrast to expectation, no above-average backbone dynamics was found for the APP transmembrane helix; the dynamics thus appears not to be optimized for cleavage.",

keywords = "Alzheimer's disease, Amide exchange, Amyloid precursor proteins, Membrane proteins, Molecular dynamics, Transmembrane domains",

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AU - Götz, Alexander

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AU - Langosch, Dieter

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KW - Alzheimer's disease

KW - Amide exchange

KW - Amyloid precursor proteins

KW - Membrane proteins

KW - Molecular dynamics

KW - Transmembrane domains

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The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics

Abstract

Keywords

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