TY - JOUR
T1 - The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia - A report from the German Registry covering the period from 1998 to 2004
AU - Bacher, Ulrike
AU - Klyuchnikov, Evgeny
AU - Zabelina, Tatjana
AU - Ottinger, Hellmut
AU - Beelen, Dietrich W.
AU - Schrezenmeier, Hubert
AU - Ehninger, Gerhard
AU - Müller, Carlheinz
AU - Berger, Jürgen
AU - Suttorp, Meinolf
AU - Kolb, Hans Jochem
AU - Kröger, Nicolaus
AU - Zander, Axel R.
PY - 2009
Y1 - 2009
N2 - Due to the recent changes in the indication to allogeneic stem cell transplantation (SCT) in chronic myeloid leukemia (CML), we retrospectively analyzed 1,716 patients with different CML stages who received an allograft from related (n=767) or unrelated donors (n=938) within the German Registry of Stem Cell Transplantation (DRST) from 1998 to 2004. Myeloablative conditioning was performed in 724/871 cases (83%), dose-reduced conditioning in 147/871 (17%). Annual transplantations were decreasing from 357 to 98 (28%) in the period of study, but the proportion of advanced cases was increasing from 32% (112/346) to 53% (50/94) of all SCTs. Stage of disease, intervals from diagnosis, and patients' age were independent prognostic parameters, while peripheral stem cells and unrelated transplantation seemed equal to bone marrow/related transplantation. This study demonstrates that allo-SCT still has an important role in advanced CML, which emphasizes the need for optimized transplantation strategies for these high-risk patients.
AB - Due to the recent changes in the indication to allogeneic stem cell transplantation (SCT) in chronic myeloid leukemia (CML), we retrospectively analyzed 1,716 patients with different CML stages who received an allograft from related (n=767) or unrelated donors (n=938) within the German Registry of Stem Cell Transplantation (DRST) from 1998 to 2004. Myeloablative conditioning was performed in 724/871 cases (83%), dose-reduced conditioning in 147/871 (17%). Annual transplantations were decreasing from 357 to 98 (28%) in the period of study, but the proportion of advanced cases was increasing from 32% (112/346) to 53% (50/94) of all SCTs. Stage of disease, intervals from diagnosis, and patients' age were independent prognostic parameters, while peripheral stem cells and unrelated transplantation seemed equal to bone marrow/related transplantation. This study demonstrates that allo-SCT still has an important role in advanced CML, which emphasizes the need for optimized transplantation strategies for these high-risk patients.
KW - Allogeneic stem cell transplantation (SCT)
KW - Chronic myeloid leukemia (CML)
KW - Dose-reduced conditioning (RIC)
KW - German Registry of Stem Cell Transplantation (DRST)
KW - Myeloablative conditioning
UR - http://www.scopus.com/inward/record.url?scp=70350341896&partnerID=8YFLogxK
U2 - 10.1007/s00277-009-0737-3
DO - 10.1007/s00277-009-0737-3
M3 - Article
C2 - 19319532
AN - SCOPUS:70350341896
SN - 0939-5555
VL - 88
SP - 1237
EP - 1247
JO - Annals of Hematology
JF - Annals of Hematology
IS - 12
ER -