The CASP8 -652 6N del promoter polymorphism and breast cancer risk: A multicenter study

Bernd Frank; Sushila H. Rigas; Justo Lorenzo Bermejo; Miriam Wiestler; Kerstin Wagner; Kari Hemminki; Malcolm W. Reed; Christian Sutter; Barbara Wappenschmidt; Sabapathy P. Balasubramanian; Alfons Meindl; Marion Kiechle; Peter Bugert; Rita K. Schmutzler; Claus R. Bartram; Christina Justenhoven; Yon Dschun Ko; Thomas Brüning; Hiltrud Brauch; Ute Hamann; Paul P.D. Pharoah; Alison M. Dunning; Karen A. Pooley; Douglas F. Easton; Angela Cox; Barbara Burwinkel

doi:10.1007/s10549-007-9752-z

The CASP8 -652 6N del promoter polymorphism and breast cancer risk: A multicenter study

Bernd Frank
, Sushila H. Rigas
, Justo Lorenzo Bermejo
, Miriam Wiestler
, Kerstin Wagner
, Kari Hemminki
, Malcolm W. Reed
, Christian Sutter
, Barbara Wappenschmidt
, Sabapathy P. Balasubramanian
, Alfons Meindl
, Marion Kiechle
, Peter Bugert
, Rita K. Schmutzler
, Claus R. Bartram
, Christina Justenhoven
, Yon Dschun Ko
, Thomas Brüning
, Hiltrud Brauch
, Ute Hamann

Paul P.D. Pharoah, Alison M. Dunning, Karen A. Pooley, Douglas F. Easton, Angela Cox, Barbara Burwinkel

Chair of Gynaecology

German Cancer Research Center
University of Sheffield
Karolinska Institutet
Heidelberg University
University of Cologne
University Hospital of Cologne
Technical University of Munich
Dr. Margarete Fischer Bosch Institute of Clinical Pharmacology
Johanniter-Krankenhaus
Max-Planck-lnstitut für Kohlenforschung
University of Cambridge

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.

Original language	English
Pages (from-to)	139-144
Number of pages	6
Journal	Breast Cancer Research and Treatment
Volume	111
Issue number	1
DOIs	https://doi.org/10.1007/s10549-007-9752-z
State	Published - Sep 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Breast cancer risk
CASP8 -652 6N del
Deletion
Sp1 binding site

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10.1007/s10549-007-9752-z

Cite this

Frank, B., Rigas, S. H., Bermejo, J. L., Wiestler, M., Wagner, K., Hemminki, K., Reed, M. W., Sutter, C., Wappenschmidt, B., Balasubramanian, S. P., Meindl, A., Kiechle, M., Bugert, P., Schmutzler, R. K., Bartram, C. R., Justenhoven, C., Ko, Y. D., Brüning, T., Brauch, H., ... Burwinkel, B. (2008). The CASP8 -652 6N del promoter polymorphism and breast cancer risk: A multicenter study. Breast Cancer Research and Treatment, 111(1), 139-144. https://doi.org/10.1007/s10549-007-9752-z

@article{0ad8bd39733c4326a5199f877f17da78,

title = "The CASP8 -652 6N del promoter polymorphism and breast cancer risk: A multicenter study",

abstract = "A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95\% confidence interval (CI), 95\% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.",

keywords = "Apoptosis, Breast cancer risk, CASP8 -652 6N del, Deletion, Sp1 binding site",

author = "Bernd Frank and Rigas, \{Sushila H.\} and Bermejo, \{Justo Lorenzo\} and Miriam Wiestler and Kerstin Wagner and Kari Hemminki and Reed, \{Malcolm W.\} and Christian Sutter and Barbara Wappenschmidt and Balasubramanian, \{Sabapathy P.\} and Alfons Meindl and Marion Kiechle and Peter Bugert and Schmutzler, \{Rita K.\} and Bartram, \{Claus R.\} and Christina Justenhoven and Ko, \{Yon Dschun\} and Thomas Br{\"u}ning and Hiltrud Brauch and Ute Hamann and Pharoah, \{Paul P.D.\} and Dunning, \{Alison M.\} and Pooley, \{Karen A.\} and Easton, \{Douglas F.\} and Angela Cox and Barbara Burwinkel",

year = "2008",

month = sep,

doi = "10.1007/s10549-007-9752-z",

language = "English",

volume = "111",

pages = "139--144",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

publisher = "Springer",

number = "1",

}

Frank, B, Rigas, SH, Bermejo, JL, Wiestler, M, Wagner, K, Hemminki, K, Reed, MW, Sutter, C, Wappenschmidt, B, Balasubramanian, SP, Meindl, A, Kiechle, M, Bugert, P, Schmutzler, RK, Bartram, CR, Justenhoven, C, Ko, YD, Brüning, T, Brauch, H, Hamann, U, Pharoah, PPD, Dunning, AM, Pooley, KA, Easton, DF, Cox, A & Burwinkel, B 2008, 'The CASP8 -652 6N del promoter polymorphism and breast cancer risk: A multicenter study', Breast Cancer Research and Treatment, vol. 111, no. 1, pp. 139-144. https://doi.org/10.1007/s10549-007-9752-z

TY - JOUR

T1 - The CASP8 -652 6N del promoter polymorphism and breast cancer risk

T2 - A multicenter study

AU - Frank, Bernd

AU - Rigas, Sushila H.

AU - Bermejo, Justo Lorenzo

AU - Wiestler, Miriam

AU - Wagner, Kerstin

AU - Hemminki, Kari

AU - Reed, Malcolm W.

AU - Sutter, Christian

AU - Wappenschmidt, Barbara

AU - Balasubramanian, Sabapathy P.

AU - Meindl, Alfons

AU - Kiechle, Marion

AU - Bugert, Peter

AU - Schmutzler, Rita K.

AU - Bartram, Claus R.

AU - Justenhoven, Christina

AU - Ko, Yon Dschun

AU - Brüning, Thomas

AU - Brauch, Hiltrud

AU - Hamann, Ute

AU - Pharoah, Paul P.D.

AU - Dunning, Alison M.

AU - Pooley, Karen A.

AU - Easton, Douglas F.

AU - Cox, Angela

AU - Burwinkel, Barbara

PY - 2008/9

Y1 - 2008/9

N2 - A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.

AB - A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.

KW - Apoptosis

KW - Breast cancer risk

KW - CASP8 -652 6N del

KW - Deletion

KW - Sp1 binding site

UR - https://www.scopus.com/pages/publications/47549086143

U2 - 10.1007/s10549-007-9752-z

DO - 10.1007/s10549-007-9752-z

M3 - Article

C2 - 17891485

AN - SCOPUS:47549086143

SN - 0167-6806

VL - 111

SP - 139

EP - 144

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 1

ER -

The CASP8 -652 6N del promoter polymorphism and breast cancer risk: A multicenter study

Abstract

UN SDGs

Keywords

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