The CASP8 -652 6N del promoter polymorphism and breast cancer risk: A multicenter study

Bernd Frank, Sushila H. Rigas, Justo Lorenzo Bermejo, Miriam Wiestler, Kerstin Wagner, Kari Hemminki, Malcolm W. Reed, Christian Sutter, Barbara Wappenschmidt, Sabapathy P. Balasubramanian, Alfons Meindl, Marion Kiechle, Peter Bugert, Rita K. Schmutzler, Claus R. Bartram, Christina Justenhoven, Yon Dschun Ko, Thomas Brüning, Hiltrud Brauch, Ute HamannPaul P.D. Pharoah, Alison M. Dunning, Karen A. Pooley, Douglas F. Easton, Angela Cox, Barbara Burwinkel

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Abstract

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalBreast Cancer Research and Treatment
Volume111
Issue number1
DOIs
StatePublished - Sep 2008
Externally publishedYes

Keywords

  • Apoptosis
  • Breast cancer risk
  • CASP8 -652 6N del
  • Deletion
  • Sp1 binding site

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