The C-terminal cytoplasmic domain of human proEGF is a negative modulator of body and organ weights in transgenic mice

Thomas Klonisch, Aleksandra Glogowska, Ana A. Gratao, Marjeta Grzech, Andreea Nistor, Mark Torchia, Ekkehard Weber, Martin Hrabé de Angelis, Birgit Rathkolb, Hoang Vu Cuong, Eckhard Wolf, Marlon R. Schneider

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We generated transgenic mice to study the in vivo role of the cytoplasmic domain of human proEGF (proEGFcyt). Post-pubertal proEGFcyt transgenic (tg) mice displayed an up to 15% reduction in body weight, including smaller kidney and brain weights as compared to control littermates. Renal histology, gene expression profiles, and functional parameters were normal. In both sexes, serum levels of IGFBP-3 were reduced. Circulating IGF-I/IGF-II levels were unchanged. Histomorphological analysis revealed isolated foci of liver necrosis specific to proEGFcyt tg mice. In conclusion, we identified proEGF cytoplasmic domain as a novel modulator of whole body and organ-specific growth in mice.

Original languageEnglish
Pages (from-to)1349-1357
Number of pages9
JournalFEBS Letters
Volume583
Issue number8
DOIs
StatePublished - 17 Apr 2009
Externally publishedYes

Keywords

  • Growth
  • IGFBP-3
  • Kidney
  • Transgenic
  • proEGF cytoplasmic domain

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