The amplifying effect of β-amyloid on cellular calcium signalling is reduced in alzheimer’s disease

Anne Eckert, Hans Förstl, Henrike Hartmann, Christian Czech, Ursula Mönning, Konrad Beyreuther, Walter E. Müller

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The amplifying effect of β-amyloid fragment 25–35 (βA25–35) on the mitogen-induced rise of free intracellular calcium in circulating lymphocytes was strongly reduced in 24 patients with Alzheimer’s disease when compared with elderly, non-demented controls. Low β-amyloid responses were significantly correlated with the presence of the apolipoprotein E 4 allele, suggesting a dose effect.

Original languageEnglish
Pages (from-to)1199-1202
Number of pages4
JournalNeuroReport
Volume6
Issue number8
DOIs
StatePublished - May 1995
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • Apolipoprotein E
  • Calcium signalling
  • Human lymphocytes
  • β-Amyloid

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