Th17 cells in central nervous system autoimmunity

Christopher Sie, Thomas Korn, Meike Mitsdoerffer

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

Multiple sclerosis (MS) is the most important autoimmune disease of the central nervous system (CNS). Its animal model experimental autoimmune encephalomyelitis (EAE) has been instrumental in defining the features of the novel T helper cell subset Th17. Conversely, the broad characterization of Th17 immune responses has substantially advanced our understanding of organ-specific autoimmunity and inspired almost a decade of immunological research. Here, we review the current knowledge on Th17 cells and their contribution to the immunopathology in EAE and MS, covering recent proceedings in the induction, modulation and effector mechanisms of this versatile T lymphocyte subset. In particular, we discuss the emerging role of mucosal immunity in the regulation of Th17 cells and CNS autoimmunity, the accumulating evidence for extensive plasticity in the Th17 subset, and their molecular mode of action in promoting this debilitating disease.

Original languageEnglish
Pages (from-to)18-27
Number of pages10
JournalExperimental Neurology
Volume262
Issue numberPart A
DOIs
StatePublished - 1 Dec 2014
Externally publishedYes

Keywords

  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis
  • Th17 cells

Fingerprint

Dive into the research topics of 'Th17 cells in central nervous system autoimmunity'. Together they form a unique fingerprint.

Cite this