Ten-year outcomes after percutaneous coronary intervention of in-stent restenosis in saphenous vein grafts

Constantin Kuna, Nadine Wiedenmayer, Christian Bradaric, Antonia Presch, Felix Voll, Sebastian Kufner, Tareq Ibrahim, Heribert Schunkert, Karl Ludwig Laugwitz, Salvatore Cassese, Adnan Kastrati, Jens Wiebe

Research output: Contribution to journalArticlepeer-review


Background: Only few data is available for long-term outcomes of patients being treated for in-stent restenosis (ISR) in saphenous vein grafts (SVG). Aims: Thus, the aim of this observational, retrospective study was to close this lack of evidence. Methods: Between January 2007 and February 2021 a total of 163 patients with 186 ISR lesions located in SVG were treated at two large-volume centers in Munich, Germany. Endpoints of interest were all-cause mortality, target lesion revascularization (TLR) and target vessel myocardial infarction (TVMI). Furthermore, recurrent ISR were assessed. Outcomes are presented as Kaplan–Meier event rates. Results: Mean age was 72.6 ± 8.6 years, 90.8% were male, 36.8% were diabetics and 42.3% presented an acute coronary syndrome. ISR were treated with DES in 64.0% and with balloon angioplasty (BA) in 36.0%. After 10 years, the rates for all-cause mortality, TVMI and TLR were 58.2%, 15.4%, and 22.6%, respectively. No statistically relevant differences were found between the types of treatment (DES or BA) regarding all-cause mortality (55.7% vs. 63.2%, p = 0.181), TVMI (13.8% vs. 18.6%, p = 0.215) and TLR (21.8% vs. 25.0%, p = 0.764). Median time between first and recurrent ISR was 270.8 days. Recurrent ISR were treated with DES in a comparable proportion as during first ISR (p = 0.075). Independent predictor of TLR is patient age (p = 0.034). The median follow-up duration was 5.1 years (75% CI 2.8; 8.5). Conclusions: Clinical event rates after intervention of ISR located in SVG are high without statistically relevant differences regarding the type of treatment. However, further studies are needed.

Original languageEnglish
Pages (from-to)646-654
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Issue number4
StatePublished - 1 Oct 2023


  • drug-coated balloon
  • drug-eluting stent
  • in-stent restenosis
  • saphenous vein graft


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