Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families

Bernd Frank; Barbara Burwinkel; Justo Lorenzo Bermejo; Asta Försti; Kari Hemminki; Richard Houlston; Elisabeth Mangold; Nils Rahner; Waltraut Friedl; Nicolaus Friedrichs; Reinhard Buettner; Christoph Engel; Markus Loeffler; Elke Holinski-Feder; Monika Morak; Gisela Keller; Hans K. Schackert; Stefan Krüger; Timm Goecke; Gabriela Moeslein; Matthias Kloor; Johannes Gebert; Erdmute Kunstmann; Karsten Schulmann; Josef Rüschoff; Peter Propping

doi:10.1016/j.canlet.2008.05.043

Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families

Bernd Frank, Barbara Burwinkel, Justo Lorenzo Bermejo, Asta Försti, Kari Hemminki, Richard Houlston, Elisabeth Mangold, Nils Rahner, Waltraut Friedl, Nicolaus Friedrichs, Reinhard Buettner, Christoph Engel, Markus Loeffler, Elke Holinski-Feder, Monika Morak, Gisela Keller, Hans K. Schackert, Stefan Krüger, Timm Goecke, Gabriela MoesleinMatthias Kloor, Johannes Gebert, Erdmute Kunstmann, Karsten Schulmann, Josef Rüschoff, Peter Propping

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Abstract

Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	Cancer Letters
Volume	271
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2008.05.043
State	Published - 18 Nov 2008

Keywords

Colorectal cancer risk
Non-synonymous single nucleotide polymorphisms
Replication studies

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2008.05.043

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Frank, B., Burwinkel, B., Bermejo, J. L., Försti, A., Hemminki, K., Houlston, R., Mangold, E., Rahner, N., Friedl, W., Friedrichs, N., Buettner, R., Engel, C., Loeffler, M., Holinski-Feder, E., Morak, M., Keller, G., Schackert, H. K., Krüger, S., Goecke, T., ... Propping, P. (2008). Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families. Cancer Letters, 271(1), 153-157. https://doi.org/10.1016/j.canlet.2008.05.043

@article{aacaf753c6ab4f88a225c1d6042ff6a3,

title = "Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families",

abstract = "Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.",

keywords = "Colorectal cancer risk, Non-synonymous single nucleotide polymorphisms, Replication studies",

author = "Bernd Frank and Barbara Burwinkel and Bermejo, {Justo Lorenzo} and Asta F{\"o}rsti and Kari Hemminki and Richard Houlston and Elisabeth Mangold and Nils Rahner and Waltraut Friedl and Nicolaus Friedrichs and Reinhard Buettner and Christoph Engel and Markus Loeffler and Elke Holinski-Feder and Monika Morak and Gisela Keller and Schackert, {Hans K.} and Stefan Kr{\"u}ger and Timm Goecke and Gabriela Moeslein and Matthias Kloor and Johannes Gebert and Erdmute Kunstmann and Karsten Schulmann and Josef R{\"u}schoff and Peter Propping",

note = "Funding Information: We wish to thank all participants who joined the study and are grateful to Julia Schmutzhard and Kerstin Wagner for their comments on the manuscript. This study was supported by the Deutsche Krebshilfe (German Cancer AID).",

year = "2008",

month = nov,

day = "18",

doi = "10.1016/j.canlet.2008.05.043",

language = "English",

volume = "271",

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journal = "Cancer Letters",

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Frank, B, Burwinkel, B, Bermejo, JL, Försti, A, Hemminki, K, Houlston, R, Mangold, E, Rahner, N, Friedl, W, Friedrichs, N, Buettner, R, Engel, C, Loeffler, M, Holinski-Feder, E, Morak, M, Keller, G, Schackert, HK, Krüger, S, Goecke, T, Moeslein, G, Kloor, M, Gebert, J, Kunstmann, E, Schulmann, K, Rüschoff, J & Propping, P 2008, 'Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families', Cancer Letters, vol. 271, no. 1, pp. 153-157. https://doi.org/10.1016/j.canlet.2008.05.043

TY - JOUR

T1 - Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families

AU - Frank, Bernd

AU - Burwinkel, Barbara

AU - Bermejo, Justo Lorenzo

AU - Försti, Asta

AU - Hemminki, Kari

AU - Houlston, Richard

AU - Mangold, Elisabeth

AU - Rahner, Nils

AU - Friedl, Waltraut

AU - Friedrichs, Nicolaus

AU - Buettner, Reinhard

AU - Engel, Christoph

AU - Loeffler, Markus

AU - Holinski-Feder, Elke

AU - Morak, Monika

AU - Keller, Gisela

AU - Schackert, Hans K.

AU - Krüger, Stefan

AU - Goecke, Timm

AU - Moeslein, Gabriela

AU - Kloor, Matthias

AU - Gebert, Johannes

AU - Kunstmann, Erdmute

AU - Schulmann, Karsten

AU - Rüschoff, Josef

AU - Propping, Peter

N1 - Funding Information: We wish to thank all participants who joined the study and are grateful to Julia Schmutzhard and Kerstin Wagner for their comments on the manuscript. This study was supported by the Deutsche Krebshilfe (German Cancer AID).

PY - 2008/11/18

Y1 - 2008/11/18

N2 - Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.

AB - Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.

KW - Colorectal cancer risk

KW - Non-synonymous single nucleotide polymorphisms

KW - Replication studies

UR - http://www.scopus.com/inward/record.url?scp=54849184900&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2008.05.043

DO - 10.1016/j.canlet.2008.05.043

M3 - Article

C2 - 18619730

AN - SCOPUS:54849184900

SN - 0304-3835

VL - 271

SP - 153

EP - 157

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families

Abstract

Keywords

UN SDGs

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