Taurolithocholate inhibits taurocholate uptake by isolated hepatocytes at low concentrations

Michael Schwenk, Leslie R. Schwarz, Helmut Greim

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The cholestatic bile acid taurolithocholate inhibits taurocholate uptake by isolated liver cells non-competitively. Inhibition is instantaneous and inversely related to the cell number in the incubate. The Kiamounts to 7 μM in the presence of 2 mg cellular protein per ml. Secretion of taurocholate by isolated liver cells is not affected by taurolithocholate up to a concentration of 50 μM. This indicates a difference between the carrier for taurocholate uptake and the carrier for taurocholate secretion. Inhibition of bile acid uptake by liver cells may be involved in the pathogenesis of lithocholate-induced cholestasis.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume298
Issue number2
DOIs
StatePublished - Jun 1977
Externally publishedYes

Keywords

  • Cholestasis
  • Isolated hepatocytes
  • Taurocholate
  • Taurolithocholate
  • Transport

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