TY - JOUR
T1 - Task type affects location of language- Positive cortical regions by repetitive navigated transcranial magnetic stimulation mapping
AU - Hauck, Theresa
AU - Tanigawa, Noriko
AU - Probst, Monika
AU - Wohlschlaeger, Afra
AU - Ille, Sebastian
AU - Sollmann, Nico
AU - Maurer, Stefanie
AU - Zimmer, Claus
AU - Ringel, Florian
AU - Meyer, Bernhard
AU - Krieg, Sandro M.
N1 - Publisher Copyright:
© 2015 Hauck et al.
PY - 2015/4/30
Y1 - 2015/4/30
N2 - Objectives Recent repetitive TMS (rTMS) mapping protocols for language mapping revealed deficits of this method, mainly in posterior brain regions. Therefore this study analyzed the impact of different language tasks on the localization of language-positive brain regions and compared their effectiveness, especially with regard to posterior brain regions. Methods Nineteen healthy, right-handed subjects performed object naming, pseudoword reading, verb generation, and action naming during rTMS language mapping of the left hemisphere. Synchronically, 5 Hz/10 pulses were applied with a 0 ms delay Results The object naming task evoked the highest error rate (14%), followed by verb generation (13%) and action naming (11%). The latter revealed more errors in posterior than in anterior areas. Pseudoword reading barely generated errors, except for phonological paraphasias. Conclusions In general, among the evaluated language tasks, object naming is the most discriminative task to detect language-positive regions via rTMS. However, other tasks might be used for more specific questions.
AB - Objectives Recent repetitive TMS (rTMS) mapping protocols for language mapping revealed deficits of this method, mainly in posterior brain regions. Therefore this study analyzed the impact of different language tasks on the localization of language-positive brain regions and compared their effectiveness, especially with regard to posterior brain regions. Methods Nineteen healthy, right-handed subjects performed object naming, pseudoword reading, verb generation, and action naming during rTMS language mapping of the left hemisphere. Synchronically, 5 Hz/10 pulses were applied with a 0 ms delay Results The object naming task evoked the highest error rate (14%), followed by verb generation (13%) and action naming (11%). The latter revealed more errors in posterior than in anterior areas. Pseudoword reading barely generated errors, except for phonological paraphasias. Conclusions In general, among the evaluated language tasks, object naming is the most discriminative task to detect language-positive regions via rTMS. However, other tasks might be used for more specific questions.
UR - https://www.scopus.com/pages/publications/84928820738
U2 - 10.1371/journal.pone.0125298
DO - 10.1371/journal.pone.0125298
M3 - Article
C2 - 25928744
AN - SCOPUS:84928820738
SN - 1932-6203
VL - 10
JO - PLoS ONE
JF - PLoS ONE
IS - 4
M1 - e0125298
ER -