Targeting cancer cells: Magnetic nanoparticles as drug carriers

Christoph Alexiou; Roswitha J. Schmid; Roland Jurgons; Marcus Kremer; Gerhard Wanner; Christian Bergemann; Ernst Huenges; Thomas Nawroth; Wolfgang Arnold; Fritz G. Parak

doi:10.1007/s00249-006-0042-1

Targeting cancer cells: Magnetic nanoparticles as drug carriers

Christoph Alexiou
, Roswitha J. Schmid
, Roland Jurgons
, Marcus Kremer
, Gerhard Wanner
, Christian Bergemann
, Ernst Huenges
, Thomas Nawroth
, Wolfgang Arnold
, Fritz G. Parak

Chair of Biomedical Physics

Research output: Contribution to journal › Article › peer-review

374 Scopus citations

Abstract

Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.

Original language	English
Pages (from-to)	446-450
Number of pages	5
Journal	European Biophysics Journal
Volume	35
Issue number	5
DOIs	https://doi.org/10.1007/s00249-006-0042-1
State	Published - May 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biological tissue
Cell biophysics
Microscopy

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10.1007/s00249-006-0042-1

Cite this

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title = "Targeting cancer cells: Magnetic nanoparticles as drug carriers",

abstract = "Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.",

keywords = "Biological tissue, Cell biophysics, Microscopy",

author = "Christoph Alexiou and Schmid, \{Roswitha J.\} and Roland Jurgons and Marcus Kremer and Gerhard Wanner and Christian Bergemann and Ernst Huenges and Thomas Nawroth and Wolfgang Arnold and Parak, \{Fritz G.\}",

note = "Funding Information: This work was supported by the Deutsche Fors-chungsgemeinschaft, Schwerpunktprogramm {\textquoteleft}{\textquoteleft}Kolloi-dale magnetische Fl{\"u}ssigkeiten{\textquoteright}{\textquoteright}",

year = "2006",

month = may,

doi = "10.1007/s00249-006-0042-1",

language = "English",

volume = "35",

pages = "446--450",

journal = "European Biophysics Journal",

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TY - JOUR

T1 - Targeting cancer cells

T2 - Magnetic nanoparticles as drug carriers

AU - Alexiou, Christoph

AU - Schmid, Roswitha J.

AU - Jurgons, Roland

AU - Kremer, Marcus

AU - Wanner, Gerhard

AU - Bergemann, Christian

AU - Huenges, Ernst

AU - Nawroth, Thomas

AU - Arnold, Wolfgang

AU - Parak, Fritz G.

N1 - Funding Information: This work was supported by the Deutsche Fors-chungsgemeinschaft, Schwerpunktprogramm ‘‘Kolloi-dale magnetische Flüssigkeiten’’

PY - 2006/5

Y1 - 2006/5

N2 - Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.

AB - Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.

KW - Biological tissue

KW - Cell biophysics

KW - Microscopy

UR - https://www.scopus.com/pages/publications/33646442910

U2 - 10.1007/s00249-006-0042-1

DO - 10.1007/s00249-006-0042-1

M3 - Article

C2 - 16447039

AN - SCOPUS:33646442910

SN - 0175-7571

VL - 35

SP - 446

EP - 450

JO - European Biophysics Journal

JF - European Biophysics Journal

IS - 5

ER -

Targeting cancer cells: Magnetic nanoparticles as drug carriers

Abstract

UN SDGs

Keywords

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