Targeted magnetic liposomes loaded with doxorubicin

Pallab Pradhan; Rinti Banerjee; Dhirendra Bahadur; Christian Koch; Olga Mykhaylyk; Christian Plank

doi:10.1007/978-1-4939-6591-5_21

Targeted magnetic liposomes loaded with doxorubicin

Pallab Pradhan
, Rinti Banerjee
, Dhirendra Bahadur
, Christian Koch
, Olga Mykhaylyk
, Christian Plank

Institute of Molecular Immunology

The Indian Institute of Technology Bombay
Technical University of Munich
Georgia Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

10 Scopus citations

Abstract

Targeted delivery systems for anticancer drugs are urgently needed to achieve maximum therapeutic efficacy by site-specific accumulation and thereby minimizing adverse effects resulting from systemic distribution of many potent anticancer drugs. We have prepared folate receptor-targeted magnetic liposomes loaded with doxorubicin, which are designed for tumor targeting through a combination of magnetic and biological targeting. Furthermore, these liposomes are designed for hyperthermia-induced drug release to be mediated by an alternating magnetic field and to be traceable by magnetic resonance imaging (MRI). Here, detailed preparation and relevant characterization techniques of targeted magnetic liposomes encapsulating doxorubicin are described.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	257-272
Number of pages	16
DOIs	https://doi.org/10.1007/978-1-4939-6591-5_21
State	Published - 2017

Publication series

Name	Methods in Molecular Biology
Volume	1522
ISSN (Print)	1064-3745

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Doxorubicin
Folate
Magnetic liposomes
Magnetic nanoparticles
Targeted

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10.1007/978-1-4939-6591-5_21

Cite this

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title = "Targeted magnetic liposomes loaded with doxorubicin",

abstract = "Targeted delivery systems for anticancer drugs are urgently needed to achieve maximum therapeutic efficacy by site-specific accumulation and thereby minimizing adverse effects resulting from systemic distribution of many potent anticancer drugs. We have prepared folate receptor-targeted magnetic liposomes loaded with doxorubicin, which are designed for tumor targeting through a combination of magnetic and biological targeting. Furthermore, these liposomes are designed for hyperthermia-induced drug release to be mediated by an alternating magnetic field and to be traceable by magnetic resonance imaging (MRI). Here, detailed preparation and relevant characterization techniques of targeted magnetic liposomes encapsulating doxorubicin are described.",

keywords = "Doxorubicin, Folate, Magnetic liposomes, Magnetic nanoparticles, Targeted",

author = "Pallab Pradhan and Rinti Banerjee and Dhirendra Bahadur and Christian Koch and Olga Mykhaylyk and Christian Plank",

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T1 - Targeted magnetic liposomes loaded with doxorubicin

AU - Pradhan, Pallab

AU - Banerjee, Rinti

AU - Bahadur, Dhirendra

AU - Koch, Christian

AU - Mykhaylyk, Olga

AU - Plank, Christian

N1 - Publisher Copyright: © Springer Science+Business Media New York 2017.

PY - 2017

Y1 - 2017

N2 - Targeted delivery systems for anticancer drugs are urgently needed to achieve maximum therapeutic efficacy by site-specific accumulation and thereby minimizing adverse effects resulting from systemic distribution of many potent anticancer drugs. We have prepared folate receptor-targeted magnetic liposomes loaded with doxorubicin, which are designed for tumor targeting through a combination of magnetic and biological targeting. Furthermore, these liposomes are designed for hyperthermia-induced drug release to be mediated by an alternating magnetic field and to be traceable by magnetic resonance imaging (MRI). Here, detailed preparation and relevant characterization techniques of targeted magnetic liposomes encapsulating doxorubicin are described.

AB - Targeted delivery systems for anticancer drugs are urgently needed to achieve maximum therapeutic efficacy by site-specific accumulation and thereby minimizing adverse effects resulting from systemic distribution of many potent anticancer drugs. We have prepared folate receptor-targeted magnetic liposomes loaded with doxorubicin, which are designed for tumor targeting through a combination of magnetic and biological targeting. Furthermore, these liposomes are designed for hyperthermia-induced drug release to be mediated by an alternating magnetic field and to be traceable by magnetic resonance imaging (MRI). Here, detailed preparation and relevant characterization techniques of targeted magnetic liposomes encapsulating doxorubicin are described.

KW - Doxorubicin

KW - Folate

KW - Magnetic liposomes

KW - Magnetic nanoparticles

KW - Targeted

UR - https://www.scopus.com/pages/publications/84995489134

U2 - 10.1007/978-1-4939-6591-5_21

DO - 10.1007/978-1-4939-6591-5_21

M3 - Chapter

C2 - 27837546

AN - SCOPUS:84995489134

T3 - Methods in Molecular Biology

SP - 257

EP - 272

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Targeted magnetic liposomes loaded with doxorubicin

Abstract

Publication series

UN SDGs

Keywords

Access to Document

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